EUS Guided Liver Biopsy - Will it Give Better Yield, More Tissue With Less Complication?

EUS Guided Liver Biopsy Proposal Titled : EUS Guided Liver Biopsy - Will it Give Better Yield , More Tissue With Less Complication ?

Liver biopsy would be done by Endoscopic Ultrasound using Acquire needle.

In this study, we aim to evaluate the tissue adequacy of EUS guided liver biopsy for parenchymal liver disease and to evaluate if diagnostic yield of left lobe is non-inferior to right lobe biopsies and to assess if combination biopsies have better yield than single lobe biopsies. Safety of the procedure and technical success would be noted.

The data would be analysed using SPSS software and needful variables and tests would be used as per statistical requirement.

Inclusion Criteria:

• Patients of any undiagnosed hepatic disease (after extensive investigation - serological as well as imaging) requiring a liver biopsy
• Patients of NAFLD who need liver biopsy
• Alcoholic hepatitis patients needing biopsy
• Any patient with unexplained transaminesemia > 1.5 times ULN needing a liver biopsy as advised by Hepatologist

Exclusion Criteria:

• Any liver Space occupying lesion suspicious of malignancy
• Platelet count <80,000
• INR > 1.5
• Pregnancy
• Severe cardiovascular and pulmonary diseases
• Recent use of anti-platelet agents within 5 days of the procedure
• Unwilling to provide informed consent