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Investigate changes in optical coherence tomography angiography of the optic nerve and macula following topical instillation of commercial preparations of netarsudil 0.02% ophthalmic solution.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Netarsudil alone | Experimental | Topical application of netarsudil 0.02% |
|
| Netarsudil plus latanoprost | Active Comparator | Topical application of netarsudil 0.02% with latanoprost 0.005% |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Netarsudil Ophthalmic | Drug | Topical instillation of commercial preparations of netarsudil 0.02% ophthalmic solution (Rhopressa and Roclatan) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Peripapillary capillary perfusion density | Mean change in peripapillary capillary perfusion as assessed using optical coherence tomography angiography | 90 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Macular capillary perfusion density | Mean change in macular capillary perfusion as assessed using optical coherence tomography angiography | 90 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mary Jo Bilicek | Contact | 210-805-3565 | bilicek@uiwtx.edu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of the Incarnate Word | Recruiting | San Antonio | Texas | 78209 | United States |
No individual participant data will be shared
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| ID | Term |
|---|---|
| D005902 | Glaucoma, Open-Angle |
| ID | Term |
|---|---|
| D005901 | Glaucoma |
| D009798 | Ocular Hypertension |
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| D000077338 | Latanoprost |
| ID | Term |
|---|---|
| D011461 | Prostaglandins F, Synthetic |
| D011465 | Prostaglandins, Synthetic |
| D011453 | Prostaglandins |
| D015777 | Eicosanoids |
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|
| D005231 |
| Fatty Acids, Unsaturated |
| D005227 | Fatty Acids |
| D008055 | Lipids |
| D012898 | Autacoids |
| D018836 | Inflammation Mediators |
| D001685 | Biological Factors |