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Researchers are trying to better understand the relationship between inflammation in adipose tissue (AT) and insulin resistance.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Lean, Healthy Controls | Active Comparator | Subjects with a body mass index (BMI) of 25 or less will have a fat tissue biopsy collected |
|
| Obese, Non-Diabetic | Experimental | Subject with a BMI between 30 and 50 kg/m2 will have fat tissue biopsy collected |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fat Tissue Biopsy | Procedure | If subjects are scheduled for a surgical procedure a fat sample will be collected during the beginning of the surgery. If subjects are not scheduled for a surgical procedure, a small sample of subcutaneous (superficial) fat tissue from subjects abdomen area will be collected. |
| Measure | Description | Time Frame |
|---|---|---|
| Number of eosinophils in adipose tissue | eosinophil number will be measured by flow cytometry in subcutaneous (superficial) adipose tissue | baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between eosinophil content and body mass index (BMI) | Measured as a linear regression between BMI (defined as the weight in Kg/height in square m; kg/m2) and eosinophil number in the fat | baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Quantification of the difference in gene methylation in eosinophils from lean and obese subjects | Gene methylation of eosinophils will be quantified in samples derived from lean and obese fat biopsy | baseline |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Elena De Filippis, MD | Mayo Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mayo Clinic | Scottsdale | Arizona | 85259 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38206766 | Derived | Hernandez JD, Li T, Ghannam H, Rau CM, Masuda MY, Madura JA 2nd, Jacobsen EA, De Filippis E. Linking adipose tissue eosinophils, IL-4, and leptin in human obesity and insulin resistance. JCI Insight. 2024 Feb 8;9(3):e170772. doi: 10.1172/jci.insight.170772. |
| Label | URL |
|---|---|
| Mayo Clinic Clinical Trials | View source |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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|
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |