Not provided
Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| P50AA027054 | U.S. NIH Grant/Contract | View source |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| National Institute on Alcohol Abuse and Alcoholism (NIAAA) | NIH |
Not provided
Not provided
Not provided
Not provided
The purpose of this study is to develop a clinical understanding of early liver transplantation (ELT) for patients with severe alcoholic hepatitis (SAH) and identify the public's opinion regarding this practice.
The research study is designed to improve the investigators' understanding of early liver transplantation for patients with severe alcoholic hepatitis. The goal of this research is twofold:
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Retrospective Cohort | Early Liver Transplantation (ELT) for patients who presented with Severe Alcoholic Hepatitis (SAH) |
| |
| Prospective Cohort 1 | Early Liver Transplantation (ELT) for patients who present with Severe Alcoholic Hepatitis (SAH) |
| |
| Prospective Cohort 2 | Orthotopic Liver Transplantation (OLT) in patient who present with Alcoholic Liver Disease (ALD) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| liver transplant | Procedure | solid organ transplant |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants who survived within 1 year post-transplant | Post-transplant survival within one year of the surgical procedure. | 1 years |
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants who self-report or have biochemically measured alcohol recidivism or relapse within 1 year post-transplant | Self-reported or biochemically measured alcohol recidivism or relapse. | 1 years |
Not provided
Inclusion Criteria for Severe Alcoholic Hepatitis patients:
Exclusion Criteria for Severe Alcoholic Hepatitis patients:
Inclusion Criteria for non-SAH comparison group:
Exclusion Criteria for non-SAH comparison group:
Not provided
Not provided
Not provided
Severe Alcoholic Hepatitis patients listed for liver transplatation at Johns Hopkins Hospital and patients undergoing liver transplantation at Johns Hopkins Hospital for Alcoholic Liver Disease
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Andrew M Cameron, MD, PhD | Johns Hopkins University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Johns Hopkins University | Baltimore | Maryland | 21205 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27280501 | Background | Lee BP, Chen PH, Haugen C, Hernaez R, Gurakar A, Philosophe B, Dagher N, Moore SA, Li Z, Cameron AM. Three-year Results of a Pilot Program in Early Liver Transplantation for Severe Alcoholic Hepatitis. Ann Surg. 2017 Jan;265(1):20-29. doi: 10.1097/SLA.0000000000001831. | |
| 29409981 | Background | Weeks SR, Sun Z, McCaul ME, Zhu H, Anders RA, Philosophe B, Ottmann SE, Garonzik Wang JM, Gurakar AO, Cameron AM. Liver Transplantation for Severe Alcoholic Hepatitis, Updated Lessons from the World's Largest Series. J Am Coll Surg. 2018 Apr;226(4):549-557. doi: 10.1016/j.jamcollsurg.2017.12.044. Epub 2018 Feb 2. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D008108 | Liver Diseases, Alcoholic |
| D019973 | Alcohol-Related Disorders |
| D012059 | Rejection, Psychology |
| D008107 | Liver Diseases |
| D006519 | Hepatitis, Alcoholic |
| D020751 | Alcohol-Induced Disorders |
| ID | Term |
|---|---|
| D004066 | Digestive System Diseases |
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
| D012919 | Social Behavior |
| D001519 | Behavior |
| D006505 | Hepatitis |
Not provided
Not provided
| ID | Term |
|---|---|
| D016031 | Liver Transplantation |
| ID | Term |
|---|---|
| D016378 | Tissue Transplantation |
| D064987 | Cell- and Tissue-Based Therapy |
| D001691 | Biological Therapy |
| D013812 | Therapeutics |
| D013505 | Digestive System Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
| D016377 | Organ Transplantation |
| D014180 | Transplantation |
Not provided
Not provided