The Effect of Oral Polymeric Diet Enriched With TGF-beta 2 (Modulen) on Clinical Response and Mucosal Healing in Adult Patients With Newly Diagnosed Crohn's Disease

The Effect of Oral Polymeric Diet Enriched With TGF-beta 2 (Modulen) on Clinical Response and Mucosal Healing in Adult Patients With Newly Diagnosed Crohn's Disease: a Prospective, Randomized Study

The aim of this study is to evaluate prospectively a possible effect of an oral polymeric diet enriched with TGF-beta 2 (Modulen) as compared to Budesonide (one of the commonly accepted treatments for Crohn's disease) on clinical response, mucosal healing and intestinal microbiota in adult patients with newly diagnosed Crohn's disease using a capsule endoscopy.

Inclusion Criteria:

• Newly diagnosed Crohn's Disease
• Mild to moderate severity

Exclusion Criteria:

• Patients who received systemic steroid or Budesonide or biological treatment
• Recent bowel surgery
• Colostomy, ileostomy
• Short bowel syndrome
• Obstructive symptoms
• Pregnancy, lactation
• Cardiac pacemaker or defibrillator
• Swallowing problems
• Uncontrolled metabolic diseases or any other condition that can be exacerbated by steroids