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The objectives of this study were to evaluate efficacy and safety of silicone cream containing Allium Cepa extract in post-cesarean surgical scars treatment. Post-cesarean surgical scars were equally seperated into 2 parts (left part and right part). Silicone cream containing Allium Cepa extract or commercial scar gel was ramdomly assigned to apply on left part or right part of the scar. They will be applied 2 times per day (morning and evening) for 3 months. Patient and Observer Scar Assessment Scale (POSAS) , Vancouver scar scale (VSS), melanin index, and erythema index (using cutometer) were used for scar evaluation at 0, 1,2,and 3 months. Moreover, adverse effects were also observed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| silicone cream containing Allium Cepa extract | Experimental | Silicone cream containing Allium Cepa extract will be applied on half of post-cesarean surgical scars 2 times per day for 3 months. |
|
| commercial scar gel | Active Comparator | Commercial scar gel will be applied on half of post-cesarean surgical scars 2 times per day for 3 months. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| silicone cream containing Allium Cepa extract | Device | silicone cream containing Allium Cepa extract contains 10% of Allium cepa bulb extract. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Patient and Observer Scar Assessment Scale | The range of score is 1 to 10. Noraml skin will be recorded as scale 1. Higher scores mean a worse outcome. | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Vancouver scar scale | The range of score is 0 to 10. Higher scores mean a worse outcome. | 3 months |
| Melanin index | Melanin index will be evaluated using cutometer. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Pornanong Aramwit, Ph.D | Contact | +66899217255 | aramwit@gmail.com |
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| ID | Term |
|---|---|
| D002921 | Cicatrix |
| ID | Term |
|---|---|
| D005355 | Fibrosis |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Commercial scar gel | Device | Commercial scar gel is a topical silicone gel. It contains cyclic and polymeric siloxanes and Vitamin C ester. |
|
| 3 months |
| Erythema index | Erythema index will be evaluated using cutometer. | 3 months |
| Adverse effect | Adverse effect will be observed in term of erythema, edema, papules, vesicles, and bullae. The range of erythema score is 0 to 3. The range of edema score is 0 to 4. Higher scores mean a worse outcome. Papules, vesicles, and bullae will be recorded as apperance or clear. | 3 months |