Invasive Pulmonary Aspergillosis and Severe Influenza

Is Invasive Pulmonary Aspergillosis a Common Complication of Severe Influenza ?

Invasive pulmonary aspergillosis (IPA) has been reported in critically ill patients with influenza infection with a highly variable incidence between 1 to 21%. Studies investigating IPA in critically ill patients with influenza infection suffer limitations in their methods. It remains unknown whether patients with influenza are more at risk of IPA than other patients hospitalized in intensive care unit and whether patients with influenza who develop IPA have specific risk factors for this infection.

Our study aims to determine the incidence of IPA in a large multicenter cohort and to identify risk factors for IPA in these patients.

Inclusion Criteria:

• Infection with influenza A or B
• Admission to one of the participating sites

Exclusion Criteria:

• age < 18
• patients with invasive pulmonary aspergillosis prior to intensive care admission
• consent withdraw