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| Name | Class |
|---|---|
| Thornhill Medical | UNKNOWN |
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This prospective, randomized control trial will use passive, isocapnic hyperventilation, applied via the ClearMateTM device (Thornhill Medical, Inc) versus controls receiving standard of care supportive management for severe alcohol intoxication to assess for enhanced ethanol elimination kinetics.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ClearMate Intervention | Experimental | Participants undergo passive isocapnic hyperventilation via the ClearMateTM device and have regular venous blood samples obtained to measure ethanol clearance kinetics. |
|
| Supportive Management | No Intervention | Participants receive standard of care, supportive management, for alcohol intoxication, having regular venous blood samples obtained to measure ethanol clearance kinetics. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ClearMateTM | Device | Passive isocapnic hyperventilation breathing circuit. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Alcohol elimination time constant | From the recorded venous ethanol blood alcohol values, an elimination time constant will be calculated | 6-24 hours |
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Inclusion Criteria:
Exclusion Criteria:
Genders will be noted and used for separate analysis due to known gender differences in alcohol elimination kinetics.
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| ID | Term |
|---|---|
| D000435 | Alcoholic Intoxication |
| ID | Term |
|---|---|
| D019973 | Alcohol-Related Disorders |
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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