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In this study, gastrointestinal anastomoses are examined with a hyperspectral camera and after this the investigators use the Standard Routine ICG-Imaging. At the end, both methods will be compared..
All gastrointestinal anastomoses were examined in all patients with written informed consent.
As Standard in our clinical Routine the tissue perfusion is measured with fluorescence Imaging and Indocyaningreen (ICG). In this study the investigators use the Hyperspectral-Camera (HSI-Camera) as new method. The measurements were performed like described before, using the TIVITA Tissue system (Diaspective Vision GmbH, Am Salzhaff, Germany). This HSI-camera provides hyperspectral images with a high spectral resolution (5 nm) in the visible and near infrared range (500-1000 nm). A RGB image and 4 false color images that represent physiologic parameters are intraoperatively provided by an analysis software. This work is focused on tissue oxygenation (StO2), which represents the relative blood oxygenation in the microcirculation of superficial tissue layers (approximately 1 mm) and the near-infrared (NIR) Perfusion Index, representing tissue layers in 4-6 mm penetration depth.
As Standard method ICG-Fluorescence Imaging is used. After the procedure the Perfusion data of both Systems is compared.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ICG | Active Comparator | Fluorescence imaging for blood Perfusion of the gastrointestinal tissue |
|
| HSI | Experimental | Hyperspectralimaging for blood Perfusion of the gastrointestinal tissue |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hyperspectral-Imaging | Diagnostic Test | Photos were taken with the hyperspectral camera of the gastrointestinal anastomosis. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Tissue oxygenation (StO2) in % | Directly after the photo has been taken, the distribution of the spectra and their intensity is evaluated with the help of computer assisted analysis software. The software calculates the tissue oxygen saturation value (StO2) in percent. These values are measured at a standardized distance from the anastomosis region. | After the intraoperative Photo is taken, within 5 minutes |
| Anastomotic Perfusion in arbitrary units | Directly after the photo has been taken, the distribution of the spectra and their intensity is evaluated with the help of computer assisted analysis software. The software calculates the tissue perfusion in arbitrary units. (Method is described in attached literature) These values are measured at a standardized distance from the anastomosis region. | After the intraoperative Photo is taken, within 5 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Boris Jansen-Winkeln, MD, PD | Contact | +49-314-97 | 17200 | boris.jansen-winkeln@medizin.uni-leipzig.de |
| Ines Gockel, MD, Prof. | Contact | +49-314-97 | 17200 | ines.gockel@medizin.uni-leipzig.de |
| Name | Affiliation | Role |
|---|---|---|
| Boris Jansen-Winkeln, MD, PD | University of Leipzig | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universitätsklinikum Leipzig - AöR | Recruiting | Leipzig | Saxony | 04103 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30712079 | Background | Jansen-Winkeln B, Holfert N, Kohler H, Moulla Y, Takoh JP, Rabe SM, Mehdorn M, Barberio M, Chalopin C, Neumuth T, Gockel I. Determination of the transection margin during colorectal resection with hyperspectral imaging (HSI). Int J Colorectal Dis. 2019 Apr;34(4):731-739. doi: 10.1007/s00384-019-03250-0. Epub 2019 Feb 2. | |
| 29637244 |
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no sharing
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| Indocyaningreen-Fluorescence imaging | Diagnostic Test | Photos were taken with the Fluorescence camera after injection of the indocyaningreen-dye of the gastrointestinal anastomosis |
|
| Jansen-Winkeln B, Maktabi M, Takoh JP, Rabe SM, Barberio M, Kohler H, Neumuth T, Melzer A, Chalopin C, Gockel I. [Hyperspectral imaging of gastrointestinal anastomoses]. Chirurg. 2018 Sep;89(9):717-725. doi: 10.1007/s00104-018-0633-2. German. |
| 32968892 | Derived | Jansen-Winkeln B, Germann I, Kohler H, Mehdorn M, Maktabi M, Sucher R, Barberio M, Chalopin C, Diana M, Moulla Y, Gockel I. Comparison of hyperspectral imaging and fluorescence angiography for the determination of the transection margin in colorectal resections-a comparative study. Int J Colorectal Dis. 2021 Feb;36(2):283-291. doi: 10.1007/s00384-020-03755-z. Epub 2020 Sep 23. |