Non-intrusive Detection of Temporary Neurologic Impairment By Opioids

Non-intrusive Detection of Temporary Neurologic Impairment By Opioids

Research is being conducted to better understand the physiologic effects (relating to the action of a drug when taken by a healthy person) of opioid use on oculomotor (relating to the motion of the eye) dynamics and to identify the presence of characteristics consistent with a specific drug or class of drugs.

Inclusion Criteria:

• Participants must be able to consent to participate themselves
• Be healthy male or non-pregnant female
• Must be able to attend in-person sessions at the Mayo Aerospace Medicine and Vestibular Research Laboratory in Scottsdale, AZ.
• Have not used opioids during the preceding 30 days
• Prior use of opioids for pain management

Exclusion Criteria:

• Women who are pregnant or breastfeeding.
• Women who are not practicing an effective form of contraception (condoms, IUD, birth control pill, diaphragm),
• Past or current history of drug or substance use.
• Significant ocular disorder.
• Positive drug test for marijuana, opioids, methamphetamines, cocaine, PCP or other controlled substances.
• History of use of psychoactive drugs within the past 30 days.
• Subjects with a history of cardiopulmonary disease including but not limited to congestive heart failure, obstructive sleep apnea, restrictive lung disease, COPD, moderate to severe asthma and oxygen dependency.
• Subjects currently taking sedatives (including benzodiazepines), muscle relaxants or disassociatives.