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One out of 10 patients undergoing surgery develops persistent post-surgical pain (PPSP). Unfortunately, available therapies for treating this pain have limited success. It is therefore of great importance to find strategies to prevent PPSP. The goal of this project is to find new screening tools that identify patients that are at risk for developing PPSP.
Tissue injury and inflammation following surgery increase the excitability of spinal nociceptive neurons ("central sensitisation", CS) with pain hypersensitivity as consequence. It is thought that CS plays an important role in persistent pain.
The first objective of this project is to assess in human patients if the propensity to develop CS manifested as secondary hyperalgesia before surgery is predictive for PPSP.
In addition, we will test if the frequency content of the resting-state EEG reflecting the initial state of the brain will be related to the propensity for developing CS and to the presence of PPSP at two months after surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| patients undergo lateral thoracotomy for primary lung cancer | Experimental |
|
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| electroencephalography (EEG) | Other | recording of resting state EEG using 64 surface electrodes |
|
| Measure | Description | Time Frame |
|---|---|---|
| mechanical pinprick perceived intensity | magnitude of the increase in sensitivity to mechanical pinprick stimuli after HFS | 1 day before surgery |
| area of increased mechanical pinprick sensitivity | spatial extent of the increased sensitivity to mechanical pinprick stimuli after HFS | 1 day before surgery |
| resting state EEG | frequency content of the resting state EEG | 1 week before surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Emanuel van den Broeke, PhD | Contact | 003227645467 | emanuel.vandenbroeke@uclouvain.be | |
| Cédric Lenoir, PhD | Contact | 003227645467 | cedric.lenoir@@uclouvain.be |
| Name | Affiliation | Role |
|---|---|---|
| Valérie Lacroix, MD, PhD | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Surgery | Not yet recruiting | Brussels | 1200 | Belgium |
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| questionnaires | Other | Hospital Anxiety Depression Scale (HADS) Neuropathic Pain questionnaire (DN4) Brief Pain Inventory (BPI) Fatigue Assessment Scale (FAS) |
|
| high frequency electrical stimulation of the forearm skin (HFS) | Other | HFS consists of transcutaneous electrical stimuli delivered as 42 Hz trains (pulse width: 2 ms) lasting 1 s. The trains are repeated 12 times. Each train is separated by 10 seconds. |
|
| cutaneous mechanical pinprick stimulation | Other | Mechanical pinprick stimuli will be applied manually by the operator on the skin using a mechanical stimulator (maximum weight 128 mN). |
|
| Saint Luc Hospital | Recruiting | Brussels | 1200 | Belgium |
|
| ID | Term |
|---|---|
| D006930 | Hyperalgesia |
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D020886 | Somatosensory Disorders |
| D012678 | Sensation Disorders |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D010146 | Pain |
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| ID | Term |
|---|---|
| D011795 | Surveys and Questionnaires |
| ID | Term |
|---|---|
| D003625 | Data Collection |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D017531 | Health Care Evaluation Mechanisms |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |
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