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Surgical occlusion of the left atrial appendage (LAAO) is sometimes performed during the cardiac surgery to reduce long-term risk of stroke.A previous study found that LAAO may be associated with increased risk of postoperative atrial fibrillation.New-onset atrial fibrillation (NOAF) after coronary artery bypass graft is related to an increased short-term and long term risk of stroke and mortality.Marshall ligament amputation may reduce the occurence of atrial fibrillation. However, little is known whether this approach is justified during the coronary artery bypass graft.Therefore, this study aimed to investigate whether LAAO and Marshall ligament amputation during off-pump coronary artery bypass was associated with reduced risks of postoperative new-onset atrial fibrillation and stroke.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Left Atrial Appendage Resection | Experimental |
| |
| off-pump coronary artery bypass | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Left Atrial Appendage Resection and Marshall Ligament Amputation | Procedure | Left Atrial Appendage Resection and Marshall Ligament Amputation during the cardiac surgery |
|
| Measure | Description | Time Frame |
|---|---|---|
| postoperative new-onset atrial fibrillation | Postoperative atrial fibrillation (POAF), defined as new-onset atrial fibrillation (AF) in the immediate period after surgery, is the most important type of secondary AF. | 7 days |
| Measure | Description | Time Frame |
|---|---|---|
| stroke | Stroke is caused by a disruption in the flow of blood to part of the brain either because of occlusion of a blood vessel in the case of acute ischemic stroke (AIS) or the rupture of a blood vessel causing bleeding in or around the brain: intracerebral hemorrhage (ICH)or subarachnoid hemorrhage (SAH)。 | 1 months,3 months, 1years, 3years, 5years. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hengchao Wu, doctor | Contact | 010-88322355 | whcwuhengchao@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Hansong Sun, doctor | Chinese Academy of Medical Sciences, Fuwai Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fuwai Hospital | Recruiting | Beijing | China |
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| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| D020521 | Stroke |
| D001281 | Atrial Fibrillation |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D001145 | Arrhythmias, Cardiac |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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