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| Name | Class |
|---|---|
| Genetics, Genomics and Crop Improvement Program, International Potato Center, Lima, Peru | UNKNOWN |
| United States Agency for International Development (USAID) | FED |
| Quadram Institute Bioscience | OTHER |
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To combat iron deficiency in Low and Middle-Income Countries, sustainable food-based solutions have to be implemented to serve populations, not only individuals. One solution is the introduction of iron biofortified staple crops on market level. Before market level introduction, the bioavailability of iron in the new biofortified Irish Potato (IP) breed needs to be assessed. In this study the investigator compares the fractional and total iron absorption after extrinsic stable isotope labelling of the new biofortified high iron IP variety and a normal market level IP variety. The study is conducted in Peruvian women of reproductive age with marginal iron status.
The 40 women enrolled will consume test meals consisting of 500g steamed and mashed high iron Irish potatoes labelled with Fe-58 daily for a period of 10 days and will then switch to the test meals consisting of 400g steamed and mashed control sweet potatoes labelled with Fe-57 for a period of 10 days. The order of test meal type is random. A baseline blood sample will be taken on the first meal feeding day prior to consumption of any test meals, study day 15 (before switching to the other test meal IP variety), on study day 26 (14 days after completion of the first test meal period) and on Day 40 (14 days after completion of the second test meal period). Erythrocyte incorporation of the stable isotope labels will be measured in these blood samples using an ICPMS and will be used to calculate fractional and total iron absorption from the two different type of test meals.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High iron Irish potato | Experimental | Meal sequence B, IP High Fe |
|
| Regular Irish potato | Active Comparator | Meal sequence A, OFSP control |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High Fe IP meal labelled with Fe-58 | Other | 500 gram steamed, mashed OFSP high Fe with 0.33 mg FeSO4-58 daily for 10 days |
|
| Measure | Description | Time Frame |
|---|---|---|
| Fractional iron absorption from both Irish Potato test meals | Proportion of stable isotope administered with test meals that has been incorporate into erythrocytes 14 days after completion of specific test meal feeding period | Measured 2 weeks after completion of feeding day sequence. Sequence consist of 2 times 10 feeding days. |
| Total iron absorption from both Irish Potato test meals | Amount of iron absorbed (mg) from the labelled test meals | Measured 2 weeks after completion of feeding day sequence. Sequence consist of 2 times 10 feeding days. |
| Measure | Description | Time Frame |
|---|---|---|
| Concentration of plasma ferritin level | Iron status marker | screening (-1), day 1 (baseline), day 15 (before switch to other test meal type) day 26 (last feeding day) and day 40 (14 days after last test meal consumption). |
| Concentration of plasma CRP level |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Reyna Liria | INN | Principal Investigator |
| Mary Penny | INN | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Instituto de Investigacion Nutricional | Lima | 1506 | Peru |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33188398 | Derived | Jongstra R, Mwangi MN, Burgos G, Zeder C, Low JW, Mzembe G, Liria R, Penny M, Andrade MI, Fairweather-Tait S, Zum Felde T, Campos H, Phiri KS, Zimmermann MB, Wegmuller R. Iron Absorption from Iron-Biofortified Sweetpotato Is Higher Than Regular Sweetpotato in Malawian Women while Iron Absorption from Regular and Iron-Biofortified Potatoes Is High in Peruvian Women. J Nutr. 2020 Dec 10;150(12):3094-3102. doi: 10.1093/jn/nxaa267. |
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| ID | Term |
|---|---|
| D018798 | Anemia, Iron-Deficiency |
| D000090463 | Iron Deficiencies |
| ID | Term |
|---|---|
| D000747 | Anemia, Hypochromic |
| D000740 | Anemia |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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| Instituto de Investigacion Nutricional, Lima, Peru | UNKNOWN |
Each woman consumes both high-iron Irish potato and a regular Irish potato variety.
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Participant is non-blinded based on differences in meal option A and B, meal option A --> B or B --> A, is assigned through investigator randomisation.
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| Control OFSP meal labelled with Fe-57 | Other | 500 gram steamed, mashed OFSP control with 0.33 mg FeSO5-57 daily for 10 days |
|
Inflammation status marker |
| screening (-1), day 1 (baseline), day 15 (before switch to other test meal type) day 26 (last feeding day) and day 40 (14 days after last test meal consumption). |
| D019189 |
| Iron Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |