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The first stage of this study will evaluates the tolerability of different concentrations of Conbercept eye drop to patients with corneal neovascularization.
The second stage of this study will evaluate the effectiveness of conbercept eye drop initially.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Conbercept eye drop (0.1mg/ mL) | Experimental | Subjects in this arm will receive 0.1mg/mL Conbercept eye drop 4 times a day, one drop at a time. |
|
| Conbercept eye drop (0.5mg/ mL) | Experimental | Subjects in this arm will receive 0.5mg/mL Conbercept eye drop 4 times a day, one drop at a time. |
|
| Conbercept eye drop (1.0mg/ mL) | Experimental | Subjects in this arm will receive 1.0mg/mL Conbercept eye drop 4 times a day, one drop at a time. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Conbercept eye drop | Drug | In the first stage, subjects will be receive Conbercept eye drop. In the second stage,subjests will revceive conbercept eye drop or placebo. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Ocular and Systemic Safety: occurrence of ocular and systemic adverse events | The occurrence of ocular and systemic adverse events was closely monitored over the course of this study. Ocular adverse events were monitored through complete ocular examinations. Systemic adverse events were identified with physical examinations. | day 14 |
| Measure | Description | Time Frame |
|---|---|---|
| The Size and Extent of Corneal Neovascularization Will be Measured by Computerized Image Analysis of Corneal Photographs Taken Throughout the Study | The efficacy of KH906 in the treatment of corneal NV was evaluated by comparing corneal photographs taken at baseline with corneal photographs taken at the follow-up visits. Percent change from baseline was measured. | day 14 and day 28 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Deng Yingping | Contact | 18980601736 | Dyp558@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Renmin Hospital of Wuhan University | Recruiting | Wuhan | Hubei | 430060 | China | |
| West China Hospital of Sichuan University |
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| ID | Term |
|---|---|
| D016510 | Corneal Neovascularization |
| ID | Term |
|---|---|
| D003316 | Corneal Diseases |
| D005128 | Eye Diseases |
| D009389 | Neovascularization, Pathologic |
| D008679 | Metaplasia |
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| Placebo | Drug | In the second stage, subjects will be receive Conbercept eys drop or a placebo. |
|
| Recruiting |
| Chengdu |
| Sichuan |
| 610000 |
| China |
|
| D010335 |
| Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |