Study of Eye Movements (EYE) as Early Markers of Brain Dysfunction (BRAIN) in Parkinson's Disease (PARK)

Study of Eye Movements (EYE) as Early Markers of Brain Dysfunction (BRAIN) in Parkinson's Disease (PARK)

Identify the neural bases of eye movements during visual tasks and their dysfunction at early stages of Parkinson disease (de novo).

Inclusion Criteria for all:

• Visual acuity normal or corrected to normal
• Affiliation to a social security scheme (copy of the vital card in support)
• Signed informed consent
• Medical examination according to the participation in the MRI examination
• MMSE score> 23/30

For Parkinson patient:

• Diagnosis of Parkinson's disease
• Presence of asymmetric bradykinesia and rest tremor and / or stiffness
• Hoehn & Yahr Stadium I-II / V

Exclusion Criteria for all:

• Unprotected Majors unable to express their consent
• Protected Major (Persons mentioned in Articles L1121-5,6 and 8 of the public health code)
• Significant hearing or motor impairment
• Past or present neuropsychiatric pathology (except benign epilepsy)
• Taking narcotics and / or drugs for neurocognitive purposes
• Existence of a severe condition in general (cardiac, respiratory, hematological, renal, hepatic, cancerous)
• Any other neurodegenerative pathology or treatment that may affect the oculomotor control

For Parkinson patient:

• Treatment for Parkinson's disease (except the inhibitors of monoaminoxidase B or MAO-B, such as selegiline and rasagiline).