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An observational cohort study will be conducted to non-invasively investigate central blood pressure and pulse wave velocity in children with kidney disease and controls. Using an oscillometric monitor, the investigators aim to non-invasively obtain the central blood pressure and pulse wave velocity (PWV), or arterial stiffness, of children with kidney disease. The investigators will also enroll age- and race-matched healthy controls and measure the same parameters for comparison. In addition, the investigators will measure PWV by standard arterial tonometry method in a subset of patients.
The specific aims of the study are as follows:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| children with kidney disease | Kidney transplant recipients age 3 to 21 years |
| |
| healthy control | Healthy children age 3 to 21 years |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| there is no intervention | Other | There is no intervention in this study. It is observational only. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Oscillometric central blood pressure | Central blood pressure as measured by oscillometric blood pressure device | cross-sectional measurement performed in patients who are between 6 months to 10 years post-transplant |
| Oscillometric pulse wave velocity | Pulse wave velocity as measured by oscillometric blood pressure device | cross-sectional measurement performed in patients who are anywhere between 6 months to 10 years post-transplant |
| Measure | Description | Time Frame |
|---|---|---|
| Body mass index (BMI) in kg/m2 | weight measured in kg and height measured in cm will be combined to determine BMI (kg/m2) | cross-sectional measurement performed in patients who are anywhere between 6 months to 10 years post-transplant |
| Waist circumference (cm) |
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Inclusion Criteria:
Exclusion Criteria:
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pediatric kidney transplant recipients and healthy controls
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Children's National Medical Cetner | Washington D.C. | District of Columbia | 20010 | United States |
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| ID | Term |
|---|---|
| D007676 | Kidney Failure, Chronic |
| ID | Term |
|---|---|
| D051436 | Renal Insufficiency, Chronic |
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
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waist circumference will be measured in cm using a flexible tape measure |
| cross-sectional measurement performed in patients who are anywhere between 6 months to 10 years post-transplant |
| Mid arm circumference (cm) | Mid arm circumference will be measured in cm using a flexible tape measure | cross-sectional measurement performed in patients who are anywhere between 6 months to 10 years post-transplant |
| D052776 |
| Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |