Immediate Breast Reconstruction With Acellular Dermal Matrix

Comparison of One-stage Direct-to-implant With Acellular Dermal Matrix and Two-stage Implant-based Breast Reconstruction: A Cohort Study

The aim of this study is to contribute to the knowledge regarding immediate implant-based BR by investigating whether the one-stage technique with ADM is superior to the two-stage expander to implant technique. Primary endpoint in first publication is postoperative complications, secondary endpoint is patient and investigator assessed aesthetic outcome. Primary endpoint in second publication is cost, secondary endpoint is patient reported outcome measures.

Inclusion Criteria:

• Skin sparing mastectomy due to breast cancer, ductal carcinoma in situ or high genetic risk of developing breast cancer
• Mastectomy weight ≤ 600 g
• Patient older than 18 years
• Ability to complete the study questionnaire
• Only for the two-stage group no later than 2 years and 4 months from breast reconstruction

Exclusion Criteria:

- smokers