The Effect of Curcumin for Treatment of Cancer Anorexia-Cachexia Syndrome in Patients With Stage III-IV of Head and Neck Cancer

A Double-blind, Placebo-controlled Randomized Trial Phase II Evaluating the Effect of Curcumin for Treatment of Cancer Anorexia-Cachexia Syndrome in Patients With Stage III-IV of Head and Neck Cancer

A study of Curcumin to prevent cancer anorexia and cachexia Syndrom in locally advance and advance stage head and neck cancer (stage III, IV)

Inclusion Criteria:

• Head and neck cancer stage III-IV
• Cancer anorexia cachexia syndrome by 2011 Cancer cachexia an International Consensus
• Enteral feeding with Nasogastric Tube or Gastrostomy
• ECOG 0-2
• Normal Bone marrow, kidneys, and liver function
• Normal function of enteral digestion and absorption

Exclusion Criteria:

• Pregnancy
• History of allergy to Curcumin or herbal medicine
• History of Herbal medicine used
• History of Billiary of obstruction
• History of Antiplatelete or anticoagulant.