This project aims to build up the comprehensive database of geriatric medicine for local Taiwanese.

This project is the pilot for the basis of establishing the schema of database and efficient procedures including subject recruitment, specimen collection, management, and measurement of samples obtained from multiple sources. We will focus on deciphering the correlation of sleep quality and the integrity of brain structure by integrating the holistic health data, socio-demographic characteristics, MRI, wearable technique, and laboratory technology including clinical lab, genotyping, metabolomics, gut microbiome, to unravel the clinical feature of which the age will effect on the frequency of sleep disturbance. This project will not only systematically study the aging effect on the sleep quality and brain structure integrity, but pave the way for exploring a variety of aging-related indications.

Inclusion Criteria:

• Participants of annual health checkup conducted by either Taipei city or Chang Gung Health and Culture Village.
• aged ≧ 60 years old.
• have medical record in Chang Gung Memorial Hospital.
• resided in the Taiwan area over 180 days in past one year.

Exclusion Criteria:

• Participants with the medical history of severe organ disorders, severe autoimmune disease, or cancer under treatment.
• Contraindications or previously failure for receiving brain computerized tomography or magnetic resonance imaging scan.
• Participants who had receive outpatient clinic follow-ups with diseases that may affect the cognitive evaluation or presentation.
• Depression with ongoing diagnosis and treatment, suicide idea or suicide behavior in the past 6 months.
• Difficulty in communication or disabilities

100 subjects with aged over 60 years old participated in annual health checkup conducted by either Taipei city or Chang Gung Health and Culture Village.