When the studies in the literature are examined, no study has been reached to examine whether median nerve mobilization causes changes in two-point discriminatory values in healthy individuals. This study aimed to investigate the effect of median nerve mobilization exercise on two-point discrimination in healthy adult male and female participants. Secondly, it was aimed to determine the role of variables such as gender, age, BMI (weight in kilograms, height in meters and weight and height will be combined to report BMI in kg/m^2), smoking, dominant extremity and physical activity level in 2-point discrimination.

Two-point discrimination is one of the most important cortical senses that require strong tactile sensitivity and the ability to distinguish two points from one point on the skin. Neural mobilization has been reported to be effective in the nerve-related waist, leg, neck, arm, and plantar heel pain, but there is still insufficient evidence for other neuromusculoskeletal problems. It has been stated that factors such as application technique, type and patient characteristics of mobilization are effective in the treatment and more comprehensive studies should be done on this subject. This study aimed to investigate the effect of median nerve mobilization exercise on two-point discrimination in healthy adult male and female participants.

120 healthy female and male adult individuals (60 females, 60 males) will be included in the study. Individuals will be divided into two groups as female and male (n = 60), and a two-point discrimination test will be performed on the palmar face of both hands from the distal phalanx, forefinger, middle finger and palm. After the evaluation, the participants in both groups were randomly divided into two groups as the exercise group (n = 30) and control group (n = 30). Participants in the exercise group will perform 2 sets of 5 repetitive Median nerve mobilization exercises (total of 20 sessions) per day for 10 days. After the exercise program, the two-point discrimination measures will be repeated in all groups.

Inclusion Criteria:

• Healthy Volunteers
• Adapt to median nerve mobilization exercise

Exclusion Criteria:

• Upper extremity neuromuscular disease
• The presence of neurological disease
• Skin diseases (burn or scar tissue in upper extremity)
• Diabetes mellitus

60 females, and 60 males