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| Name | Class |
|---|---|
| Karolinska Institutet | OTHER |
| Swedish University of Agricultural Sciences | OTHER |
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The aim of this study is to explore if an already established diet with anti-inflammatory effect in paediatric inflammatory bowel disease would have an anti-inflammatory effect in children with JIA. The diet is called specific carbohydrate diet.
Children classified with JIA, in a low-to-medium disease activity and without having changed DMARD or bDMARD in the last 12 weeks are included. Only motivated children and parents can participate. Before inclusion the family are informed orally about the study plan, the diet and practical issues regarding the study and they receive written information including for example a product list and a recipe booklet. A dietician and the principal investigator follows the child and parents during visits, by mail and phone. After the baseline visit, the family has two weeks to get used to the new diet. At baseline, after two, four and twelve weeks on the diet the child is examined, blood exams are performed and blood is stored at -70, fecal samples and urine is also collected. At inclusion and after four weeks saliva sample for bacteria is collected. The child fills in the child health assessment questionnaire, (CHAQ) for a score of the physical ability and DisabKids for an overall assessment of the childs well-being.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Children with juvenile idiopathic arthritis | Experimental | The specific carbohydrate diet has been shown to have beneficial effects on IBD and has been implemented in Seattle Children's IBD centre, with some patients using SCD either as primary or complementary therapy. The SCD is a nutritionally balanced diet focused on removing many complex carbohydrates such as grains, dairy products except for yoghurt fermented over 24 hours, vegetables rich in starch and sugars except for monosaccharides like in honey. Participants can eat meat but since it has to be unprocessed food the investigator's experience is that the amounts of meat are not very big. Fish, eggs, sea-food is allowed. Bread is baked from nut and almond flour. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Specific carbohydrate diet | Other | Specific carbohydrate diet (see arm description) |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in number of inflamed joints | Physical examination | At baseline compared to four weeks of intervention |
| Change in CHAQ, child health assessment questionnaire | A questionnaire for assessment of physical function, min-max, 0-3. A higher score means worse physical function | At baseline compared to four weeks of intervention |
| Change in overall well-being | Global assessment visual analogue scale (VAS), for the patient min-max, 0-10 cm. A higher score means worse overall well-being | At baseline compared to four weeks of intervention |
| Change in assessment of pain: visual analogue scale | Global assessment visual analogue scale (VAS) for Pain, min-max, 0-10 cm. A higher score means more pain | At baseline compared to four weeks of intervention |
| Change in assessment of morning stiffness | Number of minutes | At baseline compared to four weeks of intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Microbiota in fecal samples | 16sSrRNA and Metagenomics | At baseline compared to four weeks of intervention |
| Change in Short chain fatty acids in fecal samples | Analysed, using a HPLC-machine, Agilent technology 1100-series, presented in mg/gr |
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Inclusion Criteria:
Exclusion criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lillemor Berntson, Ass Prof | Contact | +46703706965 | lillemor.berntson@kbh.uu.se | |
| Anders Öman, Md | Contact | +4618610000 | anders.oman@kbh.uu.se |
| Name | Affiliation | Role |
|---|---|---|
| Lillemor Berntson, Ass Prof | Unit of Pediatric Rheumatology, Akademiska hospital, Uppsala University, Sweden | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Unit of Pediatric Rheumatology, Akademiska hospital | Recruiting | Uppsala | 75185 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34112181 | Derived | Berntson L. A pilot study of possible anti-inflammatory effects of the specific carbohydrate diet in children with juvenile idiopathic arthritis. Pediatr Rheumatol Online J. 2021 Jun 10;19(1):88. doi: 10.1186/s12969-021-00577-3. |
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| ID | Term |
|---|---|
| D001171 | Arthritis, Juvenile |
| D001168 | Arthritis |
| ID | Term |
|---|---|
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
| D003240 | Connective Tissue Diseases |
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| At baseline compared to four weeks of intervention |
| D017437 |
| Skin and Connective Tissue Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |