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This study is designed to compare the analgesic efficacy of different bupivacaine concentrations in pediatric patients undergoing ultrasound-guided transversus abdominis plane (TAP) block for unilateral inguinal hernia repair. In recruited 74 patients; Group 1 (n:37) received 1 mg/kg bupivakain 0.25% and Group 2 (n: 37) received 1 mg/kg bupivakain 0.125% for ultrasound-guided TAP block following standard general anaesthesia induction. FLACC (Face, Legs, Activity, Cry, Consolability) behavioral pain assessment scale was used for evaluating patients' postoperative pain levels at 15-, 30-, 45-minute and 1-, 2-, 6-, 24-hour. Tramadol 1 mg/kg was administered intravenously as rescue analgesic when FLACC score was ≥4. Total analgesic requirement, length of hospital stay and side effects were recorded.
Transversus abdominis plane (TAP) block is a safe and effective analgesia technique for paediatric patients. This study is designed to compare the analgesic efficacy of different bupivacaine concentrations in paediatric patients undergoing ultrasound-guided TAP blocks for unilateral inguinal hernia repair surgery. Seventy-four patients aging between 1 and 8 years, undergoing unilateral inguinal hernia surgery, were enrolled for this study after obtaining Institutional Ethics Committee approval and written informed consents from parents or legal guardians (2016/1281). Group 1 (n:37) received 1 mg/kg bupivakain 0.25% and Group 2 (n: 37) received 1 mg/kg bupivakain 0.125% for ultrasound-guided TAP block following standard general anaesthesia induction. All patients received remifentanil 0,1 μg/kg/h infusion and paracetamol 15 mg/kg intraoperatively, and paracetamol 4x15 mg/kg per day postoperatively. FLACC (Face, Legs, Activity, Cry, Consolability) behavioral pain assessment scale was used for evaluating patients' postoperative pain levels at 15-, 30-, 45-minute and 1-, 2-, 6-, 24-hour. Tramadol 1 mg/kg was administered intravenously as rescue analgesic when FLACC score was ≥4. Total analgesic requirement, length of hospital stay and side effects were recorded.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| TAP block with 1 mg.kg-1 bupivacaine 0.25% | Active Comparator | Patients had 1 mg.kg-1 bupivacaine 0.25% with US-guided TAP block |
|
| TAP block with 1 mg.kg-1 bupivacaine 0.125% | Active Comparator | Patients had 1 mg.kg-1 bupivacaine 0.125% with US-guided TAP block |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 1 mg.kg-1 bupivacaine 0.25% | Drug | Ultrasound-guided transversus abdominis plane block for unilateral inguinal hernia repair surgery. |
|
| Measure | Description | Time Frame |
|---|---|---|
| FLACC pediatric pain scores | It corporates five categories of behavior, each scored on 0-2 point scale so that total score ranges from 0-10. | up to 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Total analgesic requirement | Tramadol | up to 24 hours |
| First analgesic requirement time | Duration of postoperative analgesia | up to 24 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Meltem Savran Karadeniz, Assoc. Prof | Istanbul University | Principal Investigator |
| Emine Aysu Salviz, Assoc. Prof | Istanbul University | Study Chair |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36411426 | Derived | Karadeniz MS, Atasever AG, Salviz EA, Bingul ES, Ciftci HS, Dincer MB, Sungur MO. Transversus abdominis plane block with different bupivacaine concentrations in children undergoing unilateral inguinal hernia repair: a single-blind randomized clinical trial. BMC Anesthesiol. 2022 Nov 21;22(1):355. doi: 10.1186/s12871-022-01907-y. |
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| ID | Term |
|---|---|
| D002045 | Bupivacaine |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
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Ultrasound-guided TAP block was applied following standard general anaesthesia induction. All patients received remifentanil 0,1 μg/kg/h infusion and paracetamol 15 mg/kg intraoperatively, and paracetamol 4x15 mg/kg per day postoperatively.
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Seventy-four patients aging between 1 and 8 years, undergoing unilateral inguinal hernia surgery, were enrolled in the study and were randomized using closed envelope method.
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| 1 mg.kg-1 bupivacaine 0.125% | Drug | Ultrasound-guided transversus abdominis plane block for unilateral inguinal hernia repair surgery. |
|
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| Incidence of side effects | Nausea, vomiting, respiratory depression | up to 24 hours |
| The length of hospital stay | Hospitalisation hours | up to 24 hours |
| Incidence of complications | Hemotoma, infection | up to first week. |
| D000588 |
| Amines |