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The aim of this study was the describe the Immunologic biomarker profile of cerebrospinal fluid in multiple sclerosis patients
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Neuromyelitis optica with anti-MOG |
| ||
| Patients with Neuromyelitis optica with anti-AQP4 |
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| Seronegative patients with Neuromyelitis optica |
| ||
| Patients with recurrent-remitting multiple sclerosis | Patients with recurrent-remitting multiple sclerosis with medullary or optic involvement |
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| Progressive multiple sclerosis patients |
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| Symptomatic controls |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Biomarker analysis | Other | Detection of biomarker in cerebrospinal fluid |
|
| Measure | Description | Time Frame |
|---|---|---|
| Level of glial fibrillar acidic protein in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein | enzyme-linked immunosorbent assay | Baseline |
| Level of chitinase-3-like protein 1 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein | enzyme-linked immunosorbent assay | Baseline |
| Level of neurofilament in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein | enzyme-linked immunosorbent assay | Baseline |
| Level of Interleukin-6 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein | enzyme-linked immunosorbent assay | Baseline |
| Level of Interleukin-8 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein | enzyme-linked immunosorbent assay | Baseline |
| Level of C-X-C motif ligand (CXCL-13) in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein | enzyme-linked immunosorbent assay | Baseline |
| Level of Matrix metalloproteinase-9 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein |
| Measure | Description | Time Frame |
|---|---|---|
| Level of glial fibrillar acidic protein in cerebrospinal fluid in each group | enzyme-linked immunosorbent assay | Baseline |
| Level of chitinase-3-like protein 1 in cerebrospinal fluid in each group |
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Inclusion Criteria:
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Samples stored from the NOMADMUS cohort in the OFSEP collection and the NEURO collection from the Centre de Collections Biologiques Hospitalières
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| Name | Affiliation | Role |
|---|---|---|
| Eric Thouvenot | CHU Nimes | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Nimes | Nîmes | 30029 | France |
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| ID | Term |
|---|---|
| D009103 | Multiple Sclerosis |
| D009471 | Neuromyelitis Optica |
| ID | Term |
|---|---|
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D003711 | Demyelinating Diseases |
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enzyme-linked immunosorbent assay
| Baseline |
| Level of Soluble CD27 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein | enzyme-linked immunosorbent assay | Baseline |
| Level of Interleukin 10 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein | enzyme-linked immunosorbent assay | Baseline |
| Level of Interleukin 17A in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein | enzyme-linked immunosorbent assay | Baseline |
| Level of Interleukin 1B in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein | enzyme-linked immunosorbent assay | Baseline |
| Level of monocyte chemoattractant protein-1 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein | enzyme-linked immunosorbent assay | Baseline |
| Level of soluble intercellular adhesion molecule-1 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein | enzyme-linked immunosorbent assay | Baseline |
| Level of soluble vascular cell adhesion molecule-1 in cerebrospinal fluid in patients with Neuromyelitis Optica with anti- Myelin Oligodendrocyte Glycoprotein | enzyme-linked immunosorbent assay | Baseline |
enzyme-linked immunosorbent assay
| Baseline |
| Level of neurofilament in cerebrospinal fluid in each group | enzyme-linked immunosorbent assay | Baseline |
| Level of Interleukin-6 in cerebrospinal fluid in each group | enzyme-linked immunosorbent assay | Baseline |
| Level of Interleukin-8 in cerebrospinal fluid in each group | enzyme-linked immunosorbent assay | Baseline |
| Level of C-X-C motif ligand (CXCL-13) in cerebrospinal fluid in each group | enzyme-linked immunosorbent assay | Baseline |
| Level of Matrix metalloproteinase-9 in cerebrospinal fluid in each group | enzyme-linked immunosorbent assay | Baseline |
| Level of Soluble CD27 in cerebrospinal fluid in each group | enzyme-linked immunosorbent assay | Baseline |
| Level of Interleukin 10 in cerebrospinal fluid in each group | enzyme-linked immunosorbent assay | Baseline |
| Level of Interleukin 17A in cerebrospinal fluid in each group | enzyme-linked immunosorbent assay | Baseline |
| Level of Interleukin 1B in cerebrospinal fluid in each group | enzyme-linked immunosorbent assay | Baseline |
| Level of monocyte chemoattractant protein-1 in cerebrospinal fluid in each group | enzyme-linked immunosorbent assay | Baseline |
| Level of soluble intercellular adhesion molecule-1 in cerebrospinal fluid in each group | enzyme-linked immunosorbent assay | Baseline |
| Level of soluble vascular cell adhesion molecule-1 in cerebrospinal fluid in each group | enzyme-linked immunosorbent assay | Baseline |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D009188 | Myelitis, Transverse |
| D009902 | Optic Neuritis |
| D009901 | Optic Nerve Diseases |
| D003389 | Cranial Nerve Diseases |
| D005128 | Eye Diseases |