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Non-invasively neonatal cardiac output can be measured by multiple methods, but the gold standard still remains conventional echocardiography. It is accurate, but needs a long training for new users to assess cardiac function. Continuous-wave Doppler ultrasound monitor USCOM is a relatively new monitor which can perform faster and less complex cardiac function measurement, also it is easier for the operator to get trained. The aim of the study is to assess the level of agreement between cardiac output measured with conventional echocardiography and with USCOM, to present normal ranges for neonates of different gestational age and to look for early signs of hemodynamic changes during sepsis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy preterm neonate | Neonate 26 weeks to 36 weeks + 6 days of gestation, without congenital heart defects and/or hemodynamically significant fetal circulation, any respiratory therapy, nor need of supplemental oxygen. Subjects had no clinically and laboratory-identified infections. |
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| Healthy term neonate | Neonate from 37 weeks of gestation, without congenital heart defects and/or hemodynamically significant fetal circulation, any respiratory therapy, nor need of supplemental oxygen. Subjects had no clinically and laboratory-identified infections. |
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| Sick neonate | Neonate of any gestation, without congenital heart defects, with clinically and laboratory-identified infection. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ultrasound Cardiac Output Monitor (USCOM 1A) | Device | doplerometry with USCOM and echocardiograph is made for assessing central blood flow and spectroscopy with NONIN- for the blood flow in individual peripheral organs (brain and kidney) |
| Measure | Description | Time Frame |
|---|---|---|
| Weight measurement | weight in grams | 1 minute |
| Height measurement | length in centimeters | 1 minute |
| Chest and head circumference | Chest and head circumference in centimeters | 1 minute |
| Blood pressure measurement | non- invasive arterial blood pressure measurement in mmHg | 1 minute |
| Pulse rate measurement | pulse rate in beats per minute | 1 minute |
| Near- Infrared Spectroscopy for regional blood flow | One sensor on the forehead, another- on the back to check for regional blood flow in the brain and kidney with Near- Infrared Spectroscopy | 15-20 minutes |
| Echocardioscopy for left ventricular outflow tract diameter | Echocardiography for left ventricular outflow tract diameter in centimeters | 2-3 minutes |
| Echocardioscopy to measure velocity time integral | Echocardiography to measure velocity time integral at the aortic valve in centimeters. After that the software of the device calculates cardiac output. |
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Inclusion Criteria:
Exclusion Criteria:
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The study enrolled both preterm and full-term newborns of any gestational age, without congenital heart defects and/or hemodynamically significant fetal circulation, any respiratory therapy, nor need of supplemental oxygen. Subjects had no clinically and laboratory-identified infections in control group.
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| Name | Affiliation | Role |
|---|---|---|
| Vytautas Usonis, MD | Vilnius University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Vilnius University, Neonatology Centre | Vilnius | 08464 | Lithuania |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33929641 | Derived | Pliauckiene A, Liubsys A, Vankeviciene R, Usonis V. Ultrasonic cardiac output monitor provides effective non-invasive bedside measurements of neonatal cardiac output. J Clin Monit Comput. 2022 Jun;36(3):803-807. doi: 10.1007/s10877-021-00711-2. Epub 2021 Apr 30. |
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| ID | Term |
|---|---|
| D047928 | Premature Birth |
| ID | Term |
|---|---|
| D007752 | Obstetric Labor, Premature |
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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|
| 3 minutes |
| USCOM examination | USCOM 1A uses continuous wave Doppler for flow curves, which are obtained at the suprasternal notch for an optimal flow signal at the aortic valve. The software of the device calculates cardiac output then | 3-5 minutes |
| D000091642 | Urogenital Diseases |