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Studying the effects of Trans-catheter Mitral Valve Repair (TMVr) on the hemodynamics and biomarkers in patients with severe mitral valve regurgitation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Subjects undergoing TMVr | Subjects with severe, symptomatic primary mitral regurgitation (MR) scheduled to undergo a transcatheter mitral valve repair (TMVr) as standard of care will have intra-op baseline and post repair blood draws. Pre-procedure and post-procedure transthoracic echocardiograms (TTE) will assess the hemodynamic implications of the repair. |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in stroke volume index | Change in stroke volume index 10 minutes post repair to baseline stroke volume index measurement (L/m^2) | Baseline, approximately 10 mins after valve repair |
| Change in cardiac index | Change in cardiac index 10 minutes post repair to baseline cardiac index measurement (L/min/m^2) | Baseline, approximately 10 mins after valve repair |
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Inclusion Criteria:
Exclusion Criteria:
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Patients receiving a standard of care TMVR with Transcatheter edge to edge repair device for mitral regurgitation symptom alleviation.
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| Name | Affiliation | Role |
|---|---|---|
| Mackram Eleid, MD | Mayo Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mayo Clinic in Rochester | Rochester | Minnesota | 55905 | United States |
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| Label | URL |
|---|---|
| Mayo Clinic Clinical Trials | View source |
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| ID | Term |
|---|---|
| D008944 | Mitral Valve Insufficiency |
| ID | Term |
|---|---|
| D006349 | Heart Valve Diseases |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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Blood Draw