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COVID pandemia and organisational changes hinder recruitment
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The aim is to evaluate the levels of oxysterols and especially 4beta-hydroxycholesterol in patients with liver cirrhosis. Three cirrhosis cohorts are recruited: patients treated with spironolactone, patients treated with rifaximin, patients without spironolactone or rifaximin. Also three other control cohorts are recruited: patients with pneumonia, patients with Crohn's disease, patients with ulcerative colitis. The effect of the cirrhosis and its medications spironolactone and rifaximin are compared to control groups.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Liver cirrhosis with spironolactone |
| ||
| Liver cirrhosis with rifaximin |
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| Liver cirrhosis without spironolactone or rifaximin |
| ||
| Pneumonia |
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| Crohn's disease |
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| Ulcerative colitis |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| There is no intervention, only research blood samples are collected | Other | Research blood samples collected |
|
| Measure | Description | Time Frame |
|---|---|---|
| Blood 4beta-hydroxycholesterol concentration | Blood 4beta-hydroxycholesterol concentration | At the time point of the blood collection - cross-sectional. One day. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with cirrhosis, pneumonia, Crohn's disease or colitis ulcerosa treated in the ward 42 of the Oulu University Hospital
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| Name | Affiliation | Role |
|---|---|---|
| Janne Hukkanen, MD | Oulu University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Oulu University Hospital | Oulu | 90029 OYS | Finland |
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| ID | Term |
|---|---|
| D008103 | Liver Cirrhosis |
| ID | Term |
|---|---|
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D005355 | Fibrosis |
| D010335 | Pathologic Processes |
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| D013568 |
| Pathological Conditions, Signs and Symptoms |