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| ID | Type | Description | Link |
|---|---|---|---|
| R01DK122216 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | NIH |
| National Institutes of Health (NIH) | NIH |
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This study aims to; 1) investigate population differences in iron absorption between East Asians and Northern Europeans; 2) assess population differences in hormonal and biochemical determinants of Fe absorption between East Asians and Northern Europeans; and 3) to investigate genetic contributions to Fe absorption, Fe status and Fe regulatory hormones between East Asians and Northern Europeans.
Detailed description:
This study will utilize a multidisciplinary approach to identify genetic variation in genes that control iron utilization in order to shed light on the genetic basis of population differences in iron status and disease susceptibility with a long-term goal of informing population-specific dietary iron intake recommendations to minimize the risk of chronic diseases. To evaluate iron utilization, we will employ an in vivo, functional approach using an oral stable iron isotope method. Each participant will have genetic ancestry and genotyping evaluated using the Illumina Global Diversity Array-8. Study participants (n=504, aged 18-50 y) will consume 57Fe (as ferrous sulfate) in the fasted state and will then ingest a standardized breakfast and lunch meal. Two weeks after iron dosing, a blood sample will be collected from each participant and the amount of 57Fe incorporated into red blood cells will be measured using magnetic sector thermal ionization mass spectrometry. This project will fundamentally advance our understanding of ethnic differences in nutrient metabolism and iron status. It will also provide information to assist with the long-term goal of reducing the public health burden of Fe-related diseases.
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| Measure | Description | Time Frame |
|---|---|---|
| The percent of non-heme iron absorption | The percent of non-heme iron absorption will be determined by red blood cell iron incorporation of stable 57Fe | 2-week |
| The concentrations of iron and micronutrient status indicators | The concentrations or serum folate, B12, hemoglobin, hematocrit, transferrin receptor, hepcidin, erythropoietin, erythroferrone, ferritin, interleukin-6, and c-reactive protein | baseline and two-weeks post dosing |
| Genetic ancestry and characterization of iron-related genotypes | The DNA will be extracted from whole blood samples and each participant will have genetic ancestry and genotyping evaluated using the Illumina Global Diversity Array-8. | baseline |
| Habitual dietary information | Habitual dietary information will be obtained from Diet History Questionnaire III . | baseline |
| Dietary information on the study day | Detailed dietary information about all foods and beverages consumed on the study day will be obtained from the Automated Self-Administered 24-Hour Dietary Assessment Tool. | baseline |
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Inclusion Criteria:
Exclusion Criteria:
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Healthy adults from Ithaca and Rochester, NY
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| Name | Affiliation | Role |
|---|---|---|
| Kimberly O O'Brien | Cornell University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cornell University | Ithaca | New York | 14853 | United States | ||
| University of Rochester |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42044770 | Derived | Lee MR, Barad A, Bender E, Thompson J, Gu Z, Pressman EK, O'Brien KO. Differential associations between menstrual blood loss scores and iron status in East Asian and Northern European individuals: findings from a cross-sectional analysis of the Iron Genes in East Asian and Northern European Adults Study (FeGenes) cohort. Am J Clin Nutr. 2026 Jun;123(6):101326. doi: 10.1016/j.ajcnut.2026.101326. Epub 2026 Apr 25. | |
| 41895699 | Derived |
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| ID | Term |
|---|---|
| D018798 | Anemia, Iron-Deficiency |
| D019190 | Iron Overload |
| ID | Term |
|---|---|
| D000747 | Anemia, Hypochromic |
| D000740 | Anemia |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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Serum and DNA samples will be collected.
| Rochester |
| New York |
| 14642 |
| United States |
| Barad A, Xu H, Clark AG, Gu Z, Pressman EK, Ye K, O'Brien KO. A genetic association study of iron absorption in adults of East Asian or Northern European ancestry from the Iron Genes in East Asian and Northern European Adults Study (FeGenes). Am J Clin Nutr. 2026 Jun;123(6):101298. doi: 10.1016/j.ajcnut.2026.101298. Epub 2026 Mar 25. |
| 40471375 | Derived | Park CY, Barad A, Xu Y, Bender E, Thomas AK, Haller CM, Gu Z, Pressman EK, O'Brien KO. Dietary intake in East Asian and Northern European participants from the FeGenes study. Eur J Nutr. 2025 Jun 5;64(5):205. doi: 10.1007/s00394-025-03730-w. |
| 39909711 | Derived | Barad A, Xu Y, Bender E, Pressman EK, Gu Z, O'Brien KO. Differences in nonheme iron absorption between healthy adults of East Asian or Northern European ancestry from the Iron Genes in East Asian and Northern European Adults Study (FeGenes): A cross-sectional stable iron isotope study. Am J Clin Nutr. 2025 Feb;121(2):417-426. doi: 10.1016/j.ajcnut.2024.11.015. |
| 39909710 | Derived | Barad A, Xu Y, Bender E, Pressman EK, Gu Z, O'Brien KO. Iron regulatory hormones and their associations with iron status biomarkers among healthy adults of East Asian or Northern European ancestry: A cross-sectional comparison from the Iron Genes in East Asian and Northern European Adults Study (FeGenes). Am J Clin Nutr. 2025 Feb;121(2):406-416. doi: 10.1016/j.ajcnut.2024.10.018. |
| 39909709 | Derived | Barad A, Xu Y, Bender E, Kang W, Xu R, Gu Z, Pressman EK, O'Brien KO. Characterization of iron status biomarkers and hematological indices among young adults of East Asian or Northern European ancestry: A cross-sectional analysis from the Iron Genes in East Asian and Northern European Adults Study (FeGenes). Am J Clin Nutr. 2025 Feb;121(2):394-405. doi: 10.1016/j.ajcnut.2024.10.014. |
| D000090463 |
| Iron Deficiencies |
| D019189 | Iron Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |