This is a single arm, open-label, single center study to determine the safety and efficacy of Anti-CD19 CAR-T cells in patients with relapsed or refractory acute lymphoblastic leukemia and Lymphomas.

CD19 has been extensively evaluated as a therapeutic target for relapsed or refractory B cell malignancy by chimeric antigen receptor T cell therapy,this is a single arm, open-label, single center study to determine the safety and efficacy of Anti-CD19 CAR-T cells in patients with refractory acute lymphoblastic leukemia and Lymphomas.

Inclusion Criteria: Subjects diagnosed as Relapsed or Refractory acute lymphoblastic leukemia and Lymphomas ，and have no effective treatment option (such as autograft or allogeneic stem cell transplantation) and estimated survival time of the current treatment < 2 years, The specific requirements are as follows:

1. Male or female aged 18-70 years old ;
2. Estimated Survival time > 12 weeks;
3. Relapsed and refractory acute lymphoblastic leukemia and lymphoma were confirmed by physical examination, pathological examination, laboratory examination and imaging;
4. Chemotherapy failure or recurrent acute lymphoblastic leukemia and Lymphomas;
5. Glutamic-pyruvic transaminase, glutamic oxalacetic transaminase< 3 fold of normal level;
6. Bilirubin<2.0mg/dl;
7. Karnofsky Performance Status>50% at the time of screening;
8. Adequate pulmonary, renal, hepatic, and cardiac function;
9. Fail in autologous or allogenic haemopoietic stem cell transplantation;
10. Not suitable for stem cell transplantation conditions or abandoned due to conditions;
11. Free of leukocytes removal contraindications;
12. Voluntarily join CAR-T clinical trial ,Understand and sign written informed consent.

Exclusion Criteria:

1. The patient is a pregnant or breastfeeding woman, or is a woman with a pregnancy plan within six months;
2. Patients have infectious diseases (such as HIV, active tuberculosis, etc.);
3. The patient is an active hepatitis B or hepatitis C infection;
4. Feasibility assessment proves that the efficiency of transduction of lymphocyte is below 10% or the lymphocyte cannot be propagated ;
5. Abnormal vital signs;
6. Subjects with mental or psychological illness who cannot be combined with treatment and efficacy evaluation;
7. Highly allergic constitution or history of severe allergies, especially allergy to interleukin-2;
8. General infection or local severe infection, or other infection that is not controlled;
9. Dysfunction in lung, heart, kidney and brain;
10. Severe autoimmune diseases;
11. Other symptoms that are not applicable for CAR-T.