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The renal Doppler resistive index (RRI) is a noninvasive tool that has been used to assess renal perfusion in the intensive care unit (ICU) setting. It is associated with the occurrence of acute kidney injury (AKI). Many parameters have been described as influential on the values of renal RI. Red blood cell (RBC) transfusion were shown to be able to increase renal oxygenation in animal model, whereas crystalloid resuscitation did not. We sought to describe the different effect of crystalloids infusion and RBC transfusion on renal blood flow, as evaluated with doppler ultrasound
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| RBC group | Patients who received RBC transfusion |
| |
| crystalloids group | Patients who received fluid resuscitation with crystalloids |
| |
| control group | Patients not receiving RBC nor crystalloids |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transfusion | Other | RBC transfusion (1 unit) |
| |
| Crystalloids infusion |
| Measure | Description | Time Frame |
|---|---|---|
| Change in renal resistivity index (RRI) after intervention | To compare change in RRI after intervention between groups. Values over>0.70 are considered pathological. Higher values means worse outcome. | after 60 minute from intervention |
| Change Renal Venous Stasis Index (RSVI) after intervention | To compare change in RSVI after intervention between groups. Under physiological conditions, the index is zero. Higher values means worse outcome. | after 60 minute from intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Occurence of AKI | Occurence of AKI as defined by Kidney Disease: Improving Global Outcomes (KDIGO) | Once a day for 7 days |
| Variation in renal resistivity index (RRI) | To compare change in RRI after intervention between groupsValues over>0.70 are considered pathological. Higher values means worse outcome. |
| Measure | Description | Time Frame |
|---|---|---|
| correlation between arterial-venous oxygen differences and changes in renal resistivity index (RRI) after intervention | RRI values over>0.70 are considered pathological. Higher values means worse outcome. | after 24 hours from intervention |
| correlation between arterial-venous oxygen differences and changes in Renal Venous Stasis Index (RSVI) |
Inclusion Criteria:
Exclusion Criteria:
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Cohort of critically ill patients
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Università di Ferrara | Ferrara | 44121 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27993148 | Background | Zafrani L, Ergin B, Kapucu A, Ince C. Blood transfusion improves renal oxygenation and renal function in sepsis-induced acute kidney injury in rats. Crit Care. 2016 Dec 20;20(1):406. doi: 10.1186/s13054-016-1581-1. | |
| 31630601 | Background | Husain-Syed F, Birk HW, Ronco C, Schormann T, Tello K, Richter MJ, Wilhelm J, Sommer N, Steyerberg E, Bauer P, Walmrath HD, Seeger W, McCullough PA, Gall H, Ghofrani HA. Doppler-Derived Renal Venous Stasis Index in the Prognosis of Right Heart Failure. J Am Heart Assoc. 2019 Nov 5;8(21):e013584. doi: 10.1161/JAHA.119.013584. Epub 2019 Oct 19. |
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| ID | Term |
|---|---|
| D058186 | Acute Kidney Injury |
| D065227 | Transfusion Reaction |
| D000740 | Anemia |
| D004487 | Edema |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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| ID | Term |
|---|---|
| D001803 | Blood Transfusion |
| ID | Term |
|---|---|
| D001691 | Biological Therapy |
| D013812 | Therapeutics |
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| Other |
Infusion of 500 ml of balanced crystalloids |
|
| after 24 hours from intervention |
| Variation in Renal Venous Stasis Index (RSVI) | To compare change in RSVI after intervention between groups. Under physiological conditions, the index is zero. Higher values means worse outcome. | after 24 hours from intervention |
Under physiological conditions, the index is zero. Higher values means worse outcome. |
| after 24 hours from intervention |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D007154 | Immune System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |