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PI decision.
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Narrow band imaging or electronic chromoendoscopy might provide similar adenoma detection capabilities while limiting time spent when compared to conventional chromoendoscopy method.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High definition white light endoscopy | Placebo Comparator | colonoscopy performed using high definition equipment |
|
| Chromoendoscopy | Active Comparator | indigo carmine is sprayed on the colon mucosa during withdrawal phase |
|
| Narrow band imaging | Experimental | Narrow band imaging is used during withdrawal phase |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Narrow band imaging | Device | Blue light is used during withdrawal phase instead of the regular white light to highlight surface changes |
|
| Measure | Description | Time Frame |
|---|---|---|
| Adenomas per colonoscopy | total number of adenomas divided by total number of procedures | during the procedure |
| Measure | Description | Time Frame |
|---|---|---|
| Adenoma detection rate | total number of patients with adenomas divided by total number of procedures | during the procedure |
| Sessile serrated polyps per colonoscopy | total number of sessile serrated polyps divided by total number of procedures |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Douglas Rex, MD | IU | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Indiana University | Indianapolis | Indiana | 46202 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28842054 | Background | Wieszczy P, Regula J, Kaminski MF. Adenoma detection rate and risk of colorectal cancer. Best Pract Res Clin Gastroenterol. 2017 Aug;31(4):441-446. doi: 10.1016/j.bpg.2017.07.002. Epub 2017 Jul 6. | |
| 27056645 | Background | Brown SR, Baraza W, Din S, Riley S. Chromoscopy versus conventional endoscopy for the detection of polyps in the colon and rectum. Cochrane Database Syst Rev. 2016 Apr 7;4(4):CD006439. doi: 10.1002/14651858.CD006439.pub4. |
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| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| ID | Term |
|---|---|
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
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| ID | Term |
|---|---|
| D062048 | Narrow Band Imaging |
| ID | Term |
|---|---|
| D061848 | Optical Imaging |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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Randomization cards will be sealed and opened after the subject is deemed eligible for the study by the PI. This will be done in an area away from the subject but due to the nature of the study, PI can't be blinded.
| Chromoendoscopy | Other | Indigo carmine will be sprayed during withdrawal phase of colonoscopy |
|
| High definition white light endoscopy | Other | High definition equipment will be used to perform colonoscopy |
|
| during the procedure |
| Sessile serrated polyp detection rate | total number of patients with sessile serrated polyps divided by total number of procedures | during the procedure |
| Withdrawal time | Time from cecal intubation to end of the procedure | during the procedure |
| Inspection time | Time during withdrawal minus time for interventions including washing, suctioning and polypectomy or biopsies | during the procedure |
| 22258983 | Background | Nagorni A, Bjelakovic G, Petrovic B. Narrow band imaging versus conventional white light colonoscopy for the detection of colorectal polyps. Cochrane Database Syst Rev. 2012 Jan 18;1(1):CD008361. doi: 10.1002/14651858.CD008361.pub2. |
| 24751581 | Background | Leung WK, Lo OS, Liu KS, Tong T, But DY, Lam FY, Hsu AS, Wong SY, Seto WK, Hung IF, Law WL. Detection of colorectal adenoma by narrow band imaging (HQ190) vs. high-definition white light colonoscopy: a randomized controlled trial. Am J Gastroenterol. 2014 Jun;109(6):855-63. doi: 10.1038/ajg.2014.83. Epub 2014 Apr 22. |
| 30998991 | Background | Atkinson NSS, Ket S, Bassett P, Aponte D, De Aguiar S, Gupta N, Horimatsu T, Ikematsu H, Inoue T, Kaltenbach T, Leung WK, Matsuda T, Paggi S, Radaelli F, Rastogi A, Rex DK, Sabbagh LC, Saito Y, Sano Y, Saracco GM, Saunders BP, Senore C, Soetikno R, Vemulapalli KC, Jairath V, East JE. Narrow-Band Imaging for Detection of Neoplasia at Colonoscopy: A Meta-analysis of Data From Individual Patients in Randomized Controlled Trials. Gastroenterology. 2019 Aug;157(2):462-471. doi: 10.1053/j.gastro.2019.04.014. Epub 2019 Apr 15. |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |
| D008919 |
| Investigative Techniques |