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Covid crisis
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| Name | Class |
|---|---|
| Foundation for Medical Research | OTHER |
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Impact of chronic rhinosinusitis on the index of ciliary beat efficiency using fluorescent nanosticks
To date, the assessment of ciliary beat is only possible ex vivo on epithelial cells obtained from upper airway brushing. A previous prospective study (I-IsBac) showed a change in ciliary beat (in terms of coordination and frequency) in bacterial rhinosinusitis. The study of ex-vivo ciliary movement appears to be an interesting tool to understand the pathophysiology of CSRs and to guide and evaluate treatment.
A new tool to evaluate the effectiveness of the ex-vivo lash beat has been developed. This tool measures shear stress by tracking balls along the ciliary margin.
This measurement of ex-vivo shear stress by bead tracking is a validated technique. However, microbead tracking is limited by its low spatial and temporal resolution, long measurement time and heavy post-processing of acquisition data, making this method difficult to use in clinical routine. Monitoring ex-vivo fluorescent nano-batons could represent a simpler alternative for the clinician. This measurement is now made possible by Phosphate Lanthanum Lanthanum Nano-batons (LaPO4) whose luminescence is directly proportional to the shear.
The objective of this research project is to validate this new tool in patients with CSR by comparing it to a group of control subjects free of nasal inflammation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patient with Chronic Rhinosinusitis (CRS) | Other | Patients with endonasal surgery scheduled under general anesthesia for an indication of Chronic Rhinosinusitis (CRS) |
|
| Patient without Chronic Rhinosinusitis (CRS) | Other | Patients with endonasal surgery scheduled under general anesthesia for an indication of endonasal surgery for nasal obstruction or patients requiring an endonasal surgical approach such as pituitary adenomas for example. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| nasal brushing and bacteriological sample | Procedure | A nasal brushing as well as a bacteriological sample using a swab under general anesthesia at the beginning of the endonasal surgery procedure |
| Measure | Description | Time Frame |
|---|---|---|
| The shear stresss by tracking nano-batons (mPa) | The value of the shear stress by tracking nano-batons in mPa | Day of the surgical procedure under General Anesthesia |
| Measure | Description | Time Frame |
|---|---|---|
| Mucosal inflammation score (0 to 10) | Mucosal inflammation score and presence of polyps during endoscopy | Inclusion Visit |
| Presence of pus at endoscopy | Presence of pus at endoscopy |
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Inclusion Criteria:
Patient â„ 18 years old
Acceptance to participate in the protocol with signed informed consent
Affiliated or beneficiary of a social security scheme
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier Intercommunal de Créteil | Créteil | 94000 | France | |||
| HĂŽpital BicĂȘtre |
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| ID | Term |
|---|---|
| D004194 | Disease |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Inclusion Visit |
| Frequency of ciliary beat | Frequency of the ciliary beat | Day of the surgical procedure under General Anesthesia |
| Shear stress by Tracking microbeads (mPa) | Value of shear stress by tracking microbeads in mPa | Day of the surgical procedure under General Anesthesia |
| Presence of polyps at endoscopy | Presence of polyps at endoscopy | Inclusion Visit |
| coordination of cillary beat | Cillary beat coordination evaluated by microscopy | Day of the surgical procedure under General Anesthesia |
| Le Kremlin-BicĂȘtre |
| France |