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Interventional study which will assess whether an positive end expiratory pressure induced increase of central venous pressure is a valid predictor of volume responsiveness in mechanically ventilated patients after major abdominal surgery assessed by increase of cardiac output after passive leg raise.
Interventional study which will assess whether an positive end expiratory pressure induced increase of central venous pressure is a valid predictor of volume responsiveness in mechanically ventilated patients after major abdominal surgery assessed by increase of cardiac output after passive leg raise.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mechanically ventilated patients after surgery | Experimental | After ICU admission the patient's hemodynamics (MAP, HR, CO, PPV) will be measured in supine position. It will be remeasured after PEEP has been increased from +5 to +15 cmH20. Then the baseline measurement will be repeated. Then passive leg raise will be performed and all the parameters will be remeasured. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PEEP increase | Procedure | PEEP increase +5 to +15 cmH2O. PLR at 30 degrees. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Stroke volume increase after passive leg raise | Patients who have a stroke volume (measured in ml) increase of 7% or more after passive leg raise will be considered volume responsive. After the patients have been stratified into volume responders and volume non-responders, sensitivity and specificity of PEEP induced increase in CVP and pulse pressure variation will be assessed and further statistical analysis will be performed. | Within 30 seconds after PLR |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Andrej Šribar, MD, PhD | Contact | +385959404034 | andrej.sribar@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Andrej Šribar, MD, PhD | Anesthesiologist and Intensive care medicine specialist | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Dubrava | Recruiting | Zagreb | City of Zagreb | 1000 | Croatia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21622963 | Result | Geerts BF, Aarts LP, Groeneveld AB, Jansen JR. Predicting cardiac output responses to passive leg raising by a PEEP-induced increase in central venous pressure, in cardiac surgery patients. Br J Anaesth. 2011 Aug;107(2):150-6. doi: 10.1093/bja/aer125. Epub 2011 May 27. |
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Might share anonymized measured data.
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| ID | Term |
|---|---|
| D016638 | Critical Illness |
| D002303 | Cardiac Output, Low |
| ID | Term |
|---|---|
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D012816 | Signs and Symptoms |
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