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This study aims to evaluate the improvement of CeraVe moisturising lotion on the cuticle moisture of dry skin and barrier repair function.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CeraVe Moisturising Lotion | Experimental |
| |
| Half Mu ceramide body milk | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ceramides | Drug | On the 0th day, it is determined that one of the leg extensions of the participant is the test side using CeraVe Moisturising Lotion and the opposite side is the control side using Half Mu ceramide body milk by the random table. Participants are required to use the product in the morning and evening according to the "Product Use Procedures", during which other moisturizing products or emollients are prohibited. And the follow-up tests are conducted at the prescribed time. At each visit, empty packaging of products used during this period must be collected; if they are not used up as required, the remaining products must be collected. |
| Measure | Description | Time Frame |
|---|---|---|
| Self-assessment from patients | The patients fill out questionnaires and score erythema, desquamation, dryness, itching, and cleft palate on both sides of the calves (0 = none, 1 = light, 2 = medium, 3 = severe). | 17 days |
| Measure | Description | Time Frame |
|---|---|---|
| The loss of transdermal water | The percutaneous water loss value of the test site is measured continuously in an open chamber with Tewameter (TM300, Courage and Khazaka, Germany), and the measurement is performed 3 times continuously. The average value is taken after the value is stable. | 0 day, 1 day, 7 days, 14 days, 17 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Peking University First Hospital | Recruiting | Beijing | China |
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| ID | Term |
|---|---|
| D002518 | Ceramides |
| ID | Term |
|---|---|
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D020383 | Neutral Glycosphingolipids |
| D006028 | Glycosphingolipids |
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|
| Cuticle moisture |
The water content in the stratum corneum of the test site is measured 5 times with Corneometer (CM825, Course and Khazaka, Germany) and the average value is taken. |
| 0 day, 1 day, 7 days, 14 days, 17 days |
| D006017 |
| Glycolipids |
| D006001 | Glycoconjugates |
| D002241 | Carbohydrates |
| D008055 | Lipids |
| D013107 | Sphingolipids |
| D008563 | Membrane Lipids |