The Study Observes How Long Patients With Non-small Cell Lung Cancer (NSCLC) Benefit From Treatment With Epidermal Growth Factor Tyrosine Kinase Inhibitor (EGFR-TKI) When Given Either for Uncommon Mutations or for Common Mutations in the Sequence Afatinib Followed by Osimertinib

UpSwinG: Real World Study on TKI Activity in Uncommon Mutations and Sequencing Giotrif®

Non-interventional, multi-country, multi-centre cohort study based on existing data from medical records (paper or electronic) or electronic health records of patients with advanced NSCLC harbouring EGFR mutations and treated with an EGFR-TKI

Inclusion Criteria:

1. Adult patients

2. Diagnosed with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor (EGFRTKI) naive advanced EGFR mutated non-small cell lung cancer (NSCLC),

3. treated for Epidermal Growth Factor Receptor (EGFR) mutated NSCLC within regular clinical practice.

4. Informed and privacy consent signature must be obtained depending on local regulations.

   More specific inclusion criteria for each cohort are the following:

   Uncommon mutation cohort:

5. Patients harbouring uncommon or compound EGFR mutations

6. Patients who started with either afatinib (Gi(l)otrif®), gefitinib (Iressa®), erlotinib (Tarceva®), or osimertinib (Tagrisso®) in the first- or second-line setting within regular clinical practice

7. Patients must have started EGFR-TKI treatment at least 12 months prior to data entry.

Sequencing cohort:

5. Patients with common EGFR mutations (Del19, L858R) 6. Patients were treated with afatinib (Gi(l)otrif®) in the first-line setting and for acquired T790M mutation with osimertinib in the second line; 7. Patients must have started osimertinib treatment at least 10 months prior to data entry.

Patients treated with osimertinib within an early access program/ compassionate use program (EAP/CUP) are allowed

Exclusion Criteria:

1. Patients treated for EGFR mutated NSCLC within a clinical trial or participated in GioTag study.
2. Patients with active brain metastases at start of EGFR-TKI therapy (independent of treatment line)
3. For uncommon mutation cohort: Patients treated with osimertinib with no further uncommon mutation than acquired T790M Further exclusion criteria apply