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Anal Fistula can be a challenging condition to treat. Microdialysis has never before been used to examine the inner environment of anal fistula. This is now going to be performed.
Patients with anal fistula can have a reduced quality of life for years do to fistula complications. This condition is not well researched and more knowledge is needed to provide better care. Microdialysis has been used to study other organs of the body such as the brain, liver and GI-tract. Upcoming study is going to study the inner environment of the anal fistula in regards to lactate, pyruvate and glucose.
The study group is patients with anal fistula that with a need for seton treatment. Measurements with microdialysis will take place before operative procedure and one month after getting their seton inserted.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention | Other | Using microdialysis the patients inner enviorment of the anal fistula will be measured - levels of lactate, glucose and pyruvate. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| OnZurf Probe, Senzime AB, Uppsala, Sweden | Device | Probe is inserted into the fistula and measurements are made of the inner environment. |
|
| Measure | Description | Time Frame |
|---|---|---|
| measurements of glucose in anal fistula using microdialysis | measurements of glucose in fistula using microdialysis, change in value is being assessed | baseline measurement, 1 month follow up |
| Measure | Description | Time Frame |
|---|---|---|
| measurement of pyruvate in anal fistula using microdialysis | measurement of pyruvate measurements in fistula using microdialysis, change in value is being assessed | baseline measurement, 1 month follow up |
| Measure | Description | Time Frame |
|---|---|---|
| measurement of lactate in anal fistula using microdialysis | measurement of lactate in fistula using microdialysis, change in value is being assessed | baseline measurement, 1 month follow up |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Karin Strigard, Associate Professor | Contact | +4673 382 0772 | karin.strigard@umu.se | |
| Karin Adamo, PhD student | Contact | -46703364755 | karin.adamo@umu.se |
| Name | Affiliation | Role |
|---|---|---|
| Ulf Gunnarsson, Professor | University Hospital, Umeå | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Umea University Hospital | Recruiting | Umeå | Västerbotten County | 90381 | Sweden |
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| ID | Term |
|---|---|
| D012003 | Rectal Fistula |
| ID | Term |
|---|---|
| D007412 | Intestinal Fistula |
| D016154 | Digestive System Fistula |
| D004066 | Digestive System Diseases |
| D007410 | Intestinal Diseases |
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Microdialysis is used to investigate the inner enviorment of anal fistulas. The patient will be its own control with measurements at prior to intervention and after operative procedure.
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| D005767 | Gastrointestinal Diseases |
| D012002 | Rectal Diseases |
| D005402 | Fistula |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |