Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Discuss the effectiveness and safety of cord blood microtransplantation for treatment of acute myeloid leukemia
The investigators conducted a prospective, single center clinical trial to dissuss the outcomes and toxicities of HLA-mismatched cord blood infusion after chemotherapy (microtransplantation) in older patients with acute myeloid leukemia (AML)
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| cord blood group | Experimental | standard induction and consolidation chemotherapy with cord blood microtransplantation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| microtransplantation | Biological | HLA mismatched donor cord blood infusion |
|
| Measure | Description | Time Frame |
|---|---|---|
| complete remission rate | Bone marrow <5% blasts； Absolute neutrophil count >1000/mcL； Platelets ≥100,000/mcL；No residual evidence of extramedullary disease. | 1 month |
| time of hematopoietic recovery | Absolute neutrophil count >500/mcL; Platelets ≥20,000/mcL | 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| time to progression | Measured from complete remission to the relapse | 2 year |
| Measure | Description | Time Frame |
|---|---|---|
| diease free survival | Measured from complete remission to the date of death or the date of last follow-up examination. | 2 year |
| overall survival | Measured from the date of beginning therapy to the date of death or the date of last follow-up examination. |
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Wen Yao | Contact | 055162283730 | 055162283730 | yaowen0511@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Zimin Sun | The First Affiliated Hospital of USTC | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The First Affiliated Hospital of USTC | Recruiting | Hefei | 230001 | China |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| 2 year |
| rate of early mortality | Death within 4 weeks after initiation of induction therapy | 1 month |