Confocal Laser Endomicrospy in Colonic Diverticular Disease

Role of Peridiverticular and Colonic Mucosa Inflammation Based on Confocal Laser Endomicroscopy in the Prediction of Complicated Diverticular Disease

Confocal laser endomicroscopy detects inflammatory markers undetectable during high definition endoscopy. The investigators aimed to evaluate the role of peridiverticular and colonic mucosa inflammation in the prediction of the complicated diverticular disease using confocal laser endomicroscopy evaluation in the peridiverticular area in consecutive patients.

Diverticular disease of the colon is a prevalent condition in the western hemisphere. Currently there is an endoscopic classification system for classifying diverticular disease; however, white light endoscopic fails to accurately detect inflammation.

Confocal laser endomicroscopy offers a real-time, in-vivo evaluation of the colonic mucosa, with an adequate correlation to histological findings. The investigators aimed to evaluate the role of peridiverticular and colonic mucosa inflammation in the prediction of complicated diverticular disease.

Inclusion Criteria:

• Above 18 years old
• Writeen informed consent provided.
• Endoscopic visualization of diverticular disease during colonoscopy.
• Adequate bowel preparation BBPS >2 in each colon segment

Exclusion Criteria:

• Under 18 years old.
• Refuse to sign written informed consent.
• Pregnancy or nursing.
• Previous colorectal surgery
• History of colorectal cancer
• Known allergy to fluorscein
• Uncontrolled coagulopathy
• History of complicated diverticular disease
• Patients with inflammatory bowel disease
• Patients with severe comorbidities: kidney and liver failure
• NSAIDs and antibiotics two weeks prior enrollment
• Historyh of alcohol or drug abuse
• Patients with severe mental illness
• Patients with incomplete evaluation of the colon