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This study investigates the feasibility of imaging and treatment on a novel 1.5 T MR-Linac radiotherapy hybrid device.
Novel hybrid devices combine magnetic resonance imaging (MRI) and a linear accelerator in a single device. The superior soft tissue contrast compared with cone-beam computed tomography based treatment and the possibility for daily plan adaptation promise a higher precision of treatment, better target volume coverage and normal tissue sparing. In a first step the present study will test the feasibility of imaging and treatment on the 1.5 T MR-Linac.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Rectal and anal cancer | Experimental | In this arm patients with rectal and anal cancer are recruited. |
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| Prostate cancer | Experimental | In this arm patients with prostate cancer are recruited. |
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| Head and neck cancer | Experimental | In this arm patients with head and neck cancers are recruited. |
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| Esophageal cancer | Experimental | In this arm patients with esophageal cancer are recruited. |
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| Breast Cancer | Experimental | In this arm patients with breast cancer are recruited. |
|
| Central nervous system tutors | Experimental |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Radiotherapy on the MR-Linac | Radiation | Radiotherapy is performed on the 1.5 T MR Linac |
|
| Measure | Description | Time Frame |
|---|---|---|
| Feasibility of online MR guided Radiotherapy | Treatment of a patient is considered feasible when 85% of treatments were completed as planned in this patient | During every single patients treatment (i.e. between one to seven weeks after the first application of radiotherapy) |
| Measure | Description | Time Frame |
|---|---|---|
| Time analysis | Time required for online MR guided radiotherapy | During every single patients treatment (i.e. between one to seven weeks after the first application of radiotherapy) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Tübingen, Department of Radiation Oncology | Recruiting | Tübingen | Baden-Wurttemberg | 72076 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39881423 | Derived | Boeke S, Habrich J, Kubler S, Boldt J, Schick F, Nikolaou K, Kubler J, Gani C, Niyazi M, Zips D, Thorwarth D. Longitudinal assessment of diffusion-weighted imaging during magnetic resonance-guided radiotherapy in head and neck cancer. Radiat Oncol. 2025 Jan 29;20(1):15. doi: 10.1186/s13014-025-02589-9. | |
| 38785484 | Derived |
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| ID | Term |
|---|---|
| D012004 | Rectal Neoplasms |
| D006258 | Head and Neck Neoplasms |
| D008113 | Liver Neoplasms |
| D001943 | Breast Neoplasms |
| D011471 | Prostatic Neoplasms |
| D004938 | Esophageal Neoplasms |
| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
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In this arm patients with tumors of the central nervous system are recruited.
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| Palliative treatments | Experimental | In this arm patients with palliative treatments are recruited. |
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| Other | Experimental | In this arm patients with other tumors are recruited. |
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| Imaging only | Experimental | In this arm patients receive only imaging on the MR-Linac |
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| Imaging on the MR Linac | Diagnostic Test | Only imaging performed on the MR Linac |
|
| Potkrajcic V, Gani C, Fischer SG, Boeke S, Niyazi M, Thorwarth D, Voigt O, Schneider M, Monnich D, Kubler S, Boldt J, Hoffmann E, Paulsen F, Mueller AC, Wegener D. Online Adaptive MR-Guided Ultrahypofractionated Radiotherapy of Prostate Cancer on a 1.5 T MR-Linac: Clinical Experience and Prospective Evaluation. Curr Oncol. 2024 May 9;31(5):2679-2688. doi: 10.3390/curroncol31050203. |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |
| D008107 | Liver Diseases |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D005834 | Genital Neoplasms, Male |
| D014565 | Urogenital Neoplasms |
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D011469 | Prostatic Diseases |
| D052801 | Male Urogenital Diseases |
| D004935 | Esophageal Diseases |