The aim of this study to test efficacy of adding dexmedetomidine to articaine on sensory, motor and duration of analgesia during hemodialysis fistula creation under ultrasound guided supraclavicular block

Adult fifty patient with chronic renal failure on hemodialysis, scheduled for arteriovenous fistula creation under ultrasound guided supraclavicular block. Patients were randomly allocated in two group. The articaine group (group A) received 40 ml articaine hydrochloride 2% and articaine-dexmedetomidine group (group AD) received 40 ml. Of articaine 2% mixed with dexmedetomidine (1micogram/kg)

Inclusion Criteria:

• adult patient with chronic renal failure on hemodialysis scheduled for radiocephalic fistula creation

Exclusion Criteria:

• Allergy to local anesthetics.
• Infection at the site of needle insertion.
• Those having international normalized ratio more than 1.5.
• Coagulopathy.
• Neuromuscular, or severe hepatic or severe pulmonary disease.
• Those having epilepsy.
• Patients who refused to participate.

De-identified individual participants data for all primary and secondary outcome measures will be available

Within 6 month after study completion

Data access request will be reviewed by external independent reviewers panal. Request will be required to sign data access