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The investigators intend to observe the inflammatory marker procalcitonin (PCT) in comparison with patient variables on morbidity, mortality and antibiotic treatment.
The overall aim is to observe if a low PCT value can have potential in reducing unessesary antibiotic use in seasonal influenza patients.
This is an observational study of the clinical utility of early PCT measurements in seasonal influenza, with particular attention to PCT's predictive value for prognosis and bacterial respiratory superinfection. The aim is to evaluate PCT as a supplementary aid in the standard clinical evaluation of influenza patients. Patients may be included if a positive influenza test is reported within 48 hours after an initial clinical suspicion of influenza, and the hospital stay is lasting more than one day. The investigators have included 74 patients from the second half of the 2018-19 influenza season and will continue to include patients from the complete 2019-20 season.
Primary endpoints: Mortality (in-hospital and within 30 days post-discharge), bacterial respiratory tract superinfection.
Secondary endpoints: Intensive care unit stay, the proportion of patients on antibiotic use and total antibiotic use in doses and LOT ("length-of-treatment").
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| antibiotic stewardship efforts | Behavioral | The local antibiotic team plan to implement procalcitonin use among the hospital physicians. the interventions are not ready yet. |
| Measure | Description | Time Frame |
|---|---|---|
| mortality | From the national registry the investigators will register wheather or not the patient has died within day 14 and day 30, and in case of dead the date will be registered | 30 days |
| Measure | Description | Time Frame |
|---|---|---|
| antibiotic use | From a elecronical medical chart (Metavision) the investigators will search and register the type of antibiotic used, the days of treatment and the total dose given in grams | up to one year |
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Inclusion Criteria:
Exclusion Criteria:
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seasonal influenza patients, adult population
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| Name | Affiliation | Role |
|---|---|---|
| Ingrid christensen, MD | Ostfold hospital trust, Kalnes | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ostfold Hospital trust | Sarpsborg | Akershus | 1714 | Norway | ||
| Ostfold Hospital Trust |
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| ID | Term |
|---|---|
| D007251 | Influenza, Human |
| ID | Term |
|---|---|
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D009976 | Orthomyxoviridae Infections |
| D012327 | RNA Virus Infections |
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| Sarpsborg |
| Østfold fylke |
| Norway |
| D014777 | Virus Diseases |
| D012140 | Respiratory Tract Diseases |