In patients with suspected placental vascular disease who do not require hospitalization, the use of the sFlt-1 (Soluble FMS like tyrosin-kinase-1)/PlGF (Placental Growth Factor)/ assay can most likely help teams to define the best possible management.

Preeclampsia is a serious obstetric condition, affecting 2 to 5% of pregnancies and associated with maternal hypertension and renal dysfunction. It is a constant concern of obstetrical teams in the pre and post partum period. In case of diagnosis in the emergency unit, patients are usually hospitalized. However, in the case of a diagnosis of preeclampsia has been invalidated, but in presence of isolated or frustrated clinical functional signs, in the case of a history of placental vascular pathology, obstetric teams implement surveillance strategies that are binding on the patients.

The sFlt-1/ PlGF assay has a high negative predictive value for the coming week.

The use in clinical practice of these two biomarkers in the indication of negative prediction at one week could help teams in their management but the interest of this use needs to be evaluated.

Inclusion Criteria:

• Age ≥ 18 years old
• Pregnant patients term ≥ at 24 weeks of amenorrhoea (SA),
• Management in obstetrical emergencies and at the Centre Hopsitalier Intercommunal (CHI) de Créteil functional exploration center, with prescription of a vascular-renal check-up (BVR) ((proteinuria/creatinuria ratio, blood count, platelets, blood ionogram, creatinemia, transaminases (ASAT, ALAT), haptoglobulinemia, lactate dehydrogenase (LDH), TP).
• Presenting either one of the following isolated or associated clinical parameters:
• HyperTension
• urinary tape proteinuria
• functional signs of hypertension (headaches, phosphenes, accouphènes)
• live osteotendinous reflexes
• epigastric pains
• weight gain, lower limb edema, facial edema
• oliguria
• vomiting
• or one of the following isolated or associated ultrasound parameters:
• fetal hypotrophy, fetal growth deflection
• fetal Doppler abnormalities (umbilical Doppler, cerebral Doppler)
• ooligo-anamnios with intact membranes
• patient who has been informed and has given her oral non-opposition

Exclusion Criteria:

• Diagnosis of preeclampsia
• Refusal of the patient
• Patient whose symptomatology (clinical or paraclinical) leads to a decision to be hospitalized
• Age < 18 years old
• Non-affiliation to the general social security system

pregnant women suspected of placental vascular disease