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Visceral hypersensitivity is frequent in IBS population up to 60% and is correlated with severity and altered quality of life. Sleeping troubles are most frequent in IBS population. Insomnia is a frequent disorder with an important cost for healthcare. Insomnia could decrease pain threshold.
Visceral hypersensitivity was never measure in patients with insomnia. The hypothesis is IBS patients with insomnia probably have lower visceral pain threshold.
The objective is to assess pain threshold during a barostat procedure in in IBS patients with or without insomnia in comparison with healthy volunteers or patients with insomnia.
If the hypothesis are confirmed, insomnia should be look at in IBS patients and its treatments could improve visceral hypersensitivity and IBS symptoms.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy volunteers | Other |
| |
| Patients with insomnia | Other |
| |
| Patients with irritable bowel syndrome | Other |
| |
| Patients with irritable bowel syndrome and insomnia | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Barostat procedure | Procedure | Pressure threshold will be measured during the barostat procedure |
|
| Measure | Description | Time Frame |
|---|---|---|
| Pressure threshold measured during the barostat procedure | Pressure threshold measured during the barostat procedure | Day 35 |
| Measure | Description | Time Frame |
|---|---|---|
| Score at HAD anxiety and depression scale | Score at HAD anxiety and depression scale | Day 35 |
| Score at Pittsburg sleep quality index | Score at Pittsburg sleep quality index |
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Inclusion Criteria:
Healthy volunteers
- Person aged over 18 years with no IBS and no Insomnia
Patients with insomnia
- Patient aged over 18 years with no IBS and no Insomnia
Patients with IBS
- Patient aged over 18 years with IBS
patients with insomnia and IBS - Patient aged over 18 years with IBS
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Chloé MECHIOR, MD | University Hospital, Rouen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rouen University Hospital | Rouen | France |
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| ID | Term |
|---|---|
| D043183 | Irritable Bowel Syndrome |
| D007319 | Sleep Initiation and Maintenance Disorders |
| ID | Term |
|---|---|
| D003109 | Colonic Diseases, Functional |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D005767 | Gastrointestinal Diseases |
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| Anxiety and Depression Evaluation | Other | Anxiety and Depression will be measured using HAD anxiety and depression scale |
|
| Assessment of sleep quality | Other | Sleep quality will be measured using Pittsburg sleep quality index |
|
| Day 35 |
| D004066 | Digestive System Diseases |
| D020919 | Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |
| D001523 | Mental Disorders |