Remote Ischemic Conditioning of the Human Brain in Dementia Patients

Remote Ischemic Conditioning of the Human Brain in Dementia Patients (RICBDE): Protocol for a Crossover Non-pharmaceutical Intervention Study

The study investigates the incidence of remote ischemic conditioning in mild cognitive impairment and dementia patients

The investigators will study the potential neuroprotection of ischemia/reperfusion (I/R) of a peripheral organ or tissue against cerebral I/R injury in people with mild cognitive impairment as well as early and middle stage dementia.

This crossover study will be held with individuals suffering from peripheral arteriopathy that can cause intermittent claudication after structured exercise, thus inducing extensive transient leg's ischemia.

Inclusion Criteria:

• Clinical diagnosis of mild cognitive impairment
• Clinical diagnosis of mild dementia
• Clinical diagnosis of moderate dementia
• Peripheral arteriopathy

Exclusion Criteria:

• Clinical diagnosis of severe dementia
• Not being able to follow the exercise program for more than two days for any reason