Non-pulmonary Contributors of Exercise Intolerance in Patients With Cystic Fibrosis

Non-pulmonary Contributors of Exercise Intolerance in Patients With Cystic Fibrosis

The purpose of this research study is to examine if the use of antioxidant supplements impacts exercise intolerance in people with CF.

Exercise intolerance is a critical problem for people with cystic fibrosis (CF) able to predict hospitalization independent of lung function. Recent studies have suggested that certain supplements may help improving exercise intolerance.

Inclusion Criteria:

CF

• Diagnosis of CF
• Men and women (> 18 yrs. old)
• FEV1 percent predicted > 40%
• Patients with or without CF related diabetes
• Resting oxygen saturation (room air) >90%
• Traditional CF-antioxidant medications
• Ability to perform reliable/reproducible PFTs
• Clinically stable for 4 weeks (no exacerbations or need for antibiotic antioxidant within 4 weeks of testing or major change in medical status)
• Pancreatic sufficient and pancreatic insufficient patients

Exclusion Criteria:

CF

• Children 17 years old and younger
• FEV1<40% predicted
• Resting O2 saturation <90%
• Clinical diagnosis of heart disease
• Clinical diagnosis of PAH
• Febrile illness within 4 weeks of a study visit
• Antioxidant for pulmonary exacerbation within 4 weeks of a study visit
• Currently smoking, pregnant or nursing
• Vasoactive medications (i.e. nitrates, beta-blockers, Viagra etc.)
• Patients with B. Cepacia