Our study is intended to compare optimal muscle tension management or conventional anesthetic management in laparoscopic cholecystectomy about surgical condition during the surgery and other conditions after surgery at POR.

This study is intended to recruit 70 patients undergoing laparoscopic cholecystectomy, whom will be randomized to receive optimal muscle tension management or conventional anesthetic management without optimal muscle tension management. Our primary hypothesis is that optimal muscle tension management provides improved surgical conditions and less intra-abdominal pressure required. The secondary endpoints include surgical duration, intraoperative complications, total amount of muscle relaxants, respiratory and hemodynamic changes during surgery, extubation time and any events during post-anesthetic recovery.

Inclusion Criteria:

• age 20~80 years old
• ASA score : 1-2
• Regular laparoscopic cholecystectomy

Exclusion Criteria:

• Renal function impairement (eGFR < 60 ml/min/1.73m2) or ESRD
• BMI < 18.5 kg/m2 or >30 kg/m2
• History of other abdominal surgery
• Allergy to rocuronium, cisatracurium, neostigmine or sugammadex
• Emergent surgery
• Convert to open cholecystectomy

Single Blind