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Patient diagnosed with Para umbilical hernia, umbilical hernia, epigastric will be selected for the study. Sampling technique will be systematic with every 2nd patient being exposed to Gentamycin spray during mesh repair. . Each procedure took 90 to 120 minutes approximately. All patients underwent open abdominal hernioplasty operated on elective list. After placing onlay polypropylene mesh fixed with 2-0 prolene and gentamicin 160 mg injection will be sprayed over the secured mesh. Close active suction drain will be placed in subcutaneous space. Finally we will close the skin with Prolene 2-0 with vertical mattress suture or stapler.
Patients and methods:
The study will be conducted at Dow University Hospital Karachi, Ojha Campusa. The subjects included were elective patients operated for abdominal hernias. Sample size calculated for a larger study with 50% frequency, and 99% confidence levels, using Openepi was found to be 664. According to Connelly*, the sample size of pilot study should be 10% of the sample size of a larger pilot study. As it is a pilot study, the sample size for this study was found to be 66.
We will take the informed consent before including the patient in the study. Inclusion criteria Following hernia operated on elective list
Exclusion criteria
Sampling technique will be systematic with every 2nd patient being exposed to Gentamycin spray during mesh repair. . Each procedure took 90 to 120 minutes approximately. All patients underwent open abdominal hernioplasty operated on elective list. After placing onlay polypropylene mesh, fixed with 2-0 prolene and gentamicin 160 mg injection will be sprayed over the secured mesh. Close active suction drain will be placed in subcutaneous space. Finally skin will be close with Prolene 2-0 with vertical mattress suture or stapler. All patients discharge on a day care basis with follow-ups in the OPD Out patient Department for any post-operative SSI Surgical site infection for a period of two weeks. Drains will be remove once no or less than 20 ml serosanguinous/ serous discharge in 24 hours.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group; A | Open technique Hernioplasty for abdominal hernia in which 160 mg Gentamycin spray applied over the mesh |
| |
| Group; B | Open technique Hernioplasty for abdominal hernia in which no Gentamycin spray applied over the mesh |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Gentamycin | Drug | Gentamycin 160 mg spray applied over the mesh |
|
| Measure | Description | Time Frame |
|---|---|---|
| Wound infection | SSI Surgical site infection | two weeks |
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Inclusion Criteria:
Elective surgery; Para umbilical hernia, umbilical and epigastric hernia,
Exclusion Criteria:
Emergency Admission incissional hernia inguinal hernia
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Two group Study population selected from Out patient Department for elective Surgery
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Professor Shahida Parveen Afridi | Karachi | Sindh | 75270 | Pakistan |
Through research paper
6 month
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| ID | Term |
|---|---|
| D014946 | Wound Infection |
| ID | Term |
|---|---|
| D007239 | Infections |
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| ID | Term |
|---|---|
| D005839 | Gentamicins |
| ID | Term |
|---|---|
| D000617 | Aminoglycosides |
| D006027 | Glycosides |
| D002241 | Carbohydrates |
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