Effects of a Ketogenic Diet on PCOS Outcomes

Effects of a Low Calorie Mediterranean Ketogenic Diet in Women With Polycystic Ovary Syndrome

The aim of the study is to investigate the effects of a low calorie Mediterranean ketogenic diet on Polycystic Ovary Syndrome (PCOS) related outcomes.

Fourteen overweight women with diagnosis of Polycystic Ovary Syndrome (PCOS) will undergo to a low calorie ketogenic Mediterranean diet with phyoextracts (KEMEPHY) for 12 week. Changes in body weight, body mass index (BMI), fat body mass (FBM), lean body mass (LBM), visceral adipose tissue (VAT), insulin, glucose, HOMA-IR, total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL(, triglycerides (TGs), total and free testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH); dehydroepiandrosterone sulfate (DHEAs), estradiol, progesterone, sex hormone binding globulin (SHBG) and Ferriman Gallwey score will be evaluated.

Inclusion Criteria:

diagnosis of PCOS according Rotterdam Criteria (at least 2 of 3 between

• oligo/anovulation
• hyperandrogenism
• clinical (hirsutism or less commonly male pattern alopecia) or biochemical (raised FAI or free testosterone) polycystic ovaries on ultrasound Other inclusion criteria
• fertile age (18-45 years);
• BMI> 25 kg/m2,
• desire to lose weight;
• acceptance not to use contraceptives during the experimental period

Exclusion Criteria:

• pregnancy and lactation,
• hormonal therapy and/or insulin-sensitizers in the last 2 months,
• hepatic, renal and heart diseases