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The purpose of this study is to evaluate the effect of papaverine on renal artery blood flow after declamping of renal artery.
The purpose of this study is to evaluate the effect of papaverine on renal artery blood flow after declamping of renal artery in patients undergoing robot assisted partial nephrectomy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Papaverine group | Experimental | Immediately after the renal artery declamping, papaverine 30 mg (1 ample, 1 ml) is mixed with 5 ml of normal saline (total 6 ml) and sprinkled around the renal artery. |
|
| Normal saline group | Active Comparator | Immediately after the renal artery declamping, normal saline 6 ml is sprinkled around the renal artery. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Papaverine | Drug | Immediately after the renal artery declamping, papaverine 30 mg (1 ample, 1 ml) is mixed with 5 ml of normal saline (total 6 ml) and sprinkled around the renal artery. |
| Measure | Description | Time Frame |
|---|---|---|
| Renal artery blood flow | Renal artery blood flow 2 minutes after papaverine administration by doppler sonography | at 2 minutes after papaverine administration |
| Measure | Description | Time Frame |
|---|---|---|
| estimated glomerular filtration rate | estimated glomerular filtration rate using KIDGO equation | at postoperative day 0 |
| estimated glomerular filtration rate | estimated glomerular filtration rate using KIDGO equation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Young-Kug Kim, MD,PhD | Asan Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Asan medical Center | Seoul | 05505 | South Korea |
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| ID | Term |
|---|---|
| D007680 | Kidney Neoplasms |
| ID | Term |
|---|---|
| D014571 | Urologic Neoplasms |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D010208 | Papaverine |
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D044182 | Benzylisoquinolines |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
| D053610 | Opiate Alkaloids |
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| Normal saline | Drug | Immediately after the renal artery declamping, normal saline 6 ml is sprinkled around the renal artery. |
|
| at postoperative day 1 |
| estimated glomerular filtration rate | estimated glomerular filtration rate using KIDGO equation | at postoperative day 4 |
| estimated glomerular filtration rate | estimated glomerular filtration rate using KIDGO equation | at postoperative day 14 |
| estimated glomerular filtration rate | estimated glomerular filtration rate using KIDGO equation | at postoperative month 3 |
| glomerular filtration rate using renal scan | glomerular filtration rate using renal scan | at postoperative month 3 |
| D052776 |
| Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052801 | Male Urogenital Diseases |
| D007546 |
| Isoquinolines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |