Skin tags are a benign dermal disease very frequent in the general population. Their exeresis is indicated in case of discomfort of the affected person (usually because of friction or increase in size). In the minor surgery guidelines, their extraction is recommended with cryotherapy, electrocoagulation or shaving with cauterization of silver nitrate (traditional healing techniques).

This randomized clinical trial proposes its extraction with a non before referenced technique in the manuals of minor surgery and that is nowadays applied with very good outcomes in the domain of pressure ulcers, chronic wounds and, in recent years, in acute wounds; the moist healing environment. Therefore, the investigators propose the surgical exeresis of the fibroid in the most proximal part of the pendulum with the subsequent placement of a thin hydrocolloid dressing.

The objective of this trial is to compare the traditional healing with the moist healing environment in minor surgery, analyzing costs, time invested by the professional, healing time and their respective complications.

Expected results: faster healing and lower cost are expected with the new technique. By contrast, more complications are expected in the techniques of cryotherapy and silver nitrate.

Applicability / Relevance: it is a common pathology usually treated in the minor surgery office or routine visit. Therefore, it can show us which treatment leads to fewer complications for the patient and which is more cost-efficient for the health system.

Study variables:

• Sex: Dichotomous qualitative variable: woman/man. Clinical history collection.
• Age: Discrete quantitative variable in years from the date of birth included in the clinical history.
• Family history. Dichotomous qualitative variable: yes/no. According to the interview with the participant, the family history of first and second degree skin tags will be considered.
• Location of the lesion. Qualitative variable categorized in 6 items: Trunk/ armpit/ neck/ inguinal/ upper extremity/ lower extremity.
• Diabetes Dichotomous qualitative variable: yes/no. According to conditioning factors and problems in the clinical history and interview with the participant. There are studies that relate insulin resistance with the presence or not of skin tags 37, 38. To be able to study if the results obtained are independent of the variable of suffering from DM.
• Cost: Continuous quantitative variable, expressed in euros. The cost will include the performance of the technique in the first minor surgery visit, the post-surgical cures and the follow-up visits. The standardized cost of each of the interventions has been calculated according to the different techniques for approaching skin tag, from the prices published in DOGC 6326 of 1 March 2013 Resolution SLT/353/2013 of 13 February on the review of public price corresponding to the health services provided by the Institut Català de la Salut. Apart from the price for the minor surgery visit of the different approaches, the price of the follow-up visits has been calculated in case of prolonged healing time of the lesion or the appearance of complications (infection or non-viable tissue...).
• Healing time: Discrete quantitative variable expressed in days. It will be considered 'healing' when the lesion has concluded the phases of inflammation and granulation/epithelialization. It will be the moment when it does not require any cure and lacks non-viable tissue (the days in the remodeling phase in which the participant uses skin care such as moisturizing, sun protection... will not be counted). For the monitoring of this variable, in the follow-up visits, the state of scarring will be evaluated and if it is already healed, it will be asked on what day prior to the visit, the lesion did not need any special cure and lacked non-viable tissue.
• Time invested by the professional: Discrete quantitative variable expressed in minutes. The time invested in each visit will be recorded until it is healed.
• Complications:

Infection: Dichotomous qualitative variable: yes/no. Infection is considered when the wound shows inflammation signs of infection.

• Devitalized tissue: Dichotomous qualitative variable: yes/no. The appearance of slough will be observed.

• Technique: Qualitative variable categorized in 4 items:

  • Dry Cure - Electrocoagulation.
  • Dry Cure - Cryotherapy.
  • Dry Cure - Silver Nitrate.
  • Cure in a moist healing environment.

Inclusion Criteria:

• Injuries that, by increasing in size or by rubbing with some element of clothing, cause discomfort for the user (pain, bleeding, ...).
• Only small skin tags (≤0,5x0,5cm) will be accepted for study.
• People who voluntarily agree to enter the clinical trial and sign the Informed Consent.

Exclusion Criteria:

• Immunosuppressed patients: people with immunosuppressive treatments, long-lasting corticoids, chemotherapy or radiotherapy, biological treatments and immunosuppressive diseases such as HIV infection, hematological diseases, transplants... (these people have a compromised immune response and are more susceptible to infections and their complications.
• Patients with anticoagulant treatment: oral anticoagulants antagonists of vitamin K (AVK: acenocoumarol, warfarin) or direct oral anticoagulants (DOACs: apixaban, dabigatran, rivaroxaban, edoxaban).
• According to location: those areas of greater risk of infection due to their location (genital areas) or those areas with aesthetic compromise.
• According to size: in order to ensure the homogeneity of the lesions, large lesions (larger than 0,5x0,5cm) will be discarded.
• Allergic to silver (according to medical history or patient reference).
• Lesions of doubtful diagnosis. Skin tag is a benign lesion but any doubt in its diagnostic classification will be an exclusion criterion in its participation. In these cases, it will be treated according to the centre usual minor surgery protocol for study.