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A obvational prospective cohort study of men undergoing IUI, IVF and ICSI treatment in Denmark. The aim is to asses the impact of sperm DNA damage, measured as DNA fragmentation index (DFI), on reproductive outcomes after assisted reproductive technology (ART).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| IUI - Insemination | Males of couples undergoing their first IUI treatment | ||
| IVF - In vitro fertilisation | Males of couples undergoing their first IVF treatment. Including males of couples who have had previous IUI treatments. | ||
| ICSI - Micro Insemination | Males of couples undergoing their first ICSI treatment. Including males of couples who have had previous IUI treatments. |
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| Measure | Description | Time Frame |
|---|---|---|
| Number of particpants achieving live birth | Birth of a living child after week 23. Registered through self-reported schemes sent to the clinic. | week 23-42 of pregnancy |
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants with clinical pregnancy | Measurement of heart beat by ultrasound scan | week 7-8 of pregnancy |
| Number of participants with biochemical pregnancy | Increase in serum hCG levels |
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Inclusion Criteria:
Exclusion Criteria:
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Males of couples attending Skive fertility Clinic
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fertility Clinic, Skive Regional Hospital | Recruiting | Skive | Denmark |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| D007248 | Infertility, Male |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D005832 | Genital Diseases, Male |
| D052801 | Male Urogenital Diseases |
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Semen
| Day 14-17 of pregnancy |
| Cumulative live birth rate | Live births originating from one controlled stimulation. | 9-24 months after inclusion |